Study On Relationship Between Serum Level Of Adipocyte Fatty Acid-binding Protein Combine Interieukin-6and Coronary Heart Disease

Objective: Obeserve the difference of serum A-FABP between patients in differentlesions of CHD（coronary heart disease）and normal coronary arteries. Analyse thecorrelation between serum A-FABP with the occurrence and pathological damage ofCHD. Compare the changes in A-FABP、interleukin-6(IL-6) and high-sensitivityc-reactive protein (hs-CRP) and then discuss the possible mechanism of A-FABP inthe occurrence and development of CHD.Methods: Choose from the patients who underwent Coronary angiography in ourhospital from November2010to October2011.Among the patients there were64cases proved to be with Coronary heart disease, including20cases with stable angina;24cases with unstable angina pectoris;20cases with acute myocardial infarction and24controls with normal coronary arteris in the same period. Serm levels of A-FABPand interleukin-6（IL-6）were detected by ELISA. And serm level of hs-CRP wasdetected by immunoturbidimetry. Experimental data were processed by SPSS16.0statistical analysis software.Results:1. The level of serum adipocyte fatty acid-binding protein was significantly higher inpatients with CHD than in the control group [7.76ng/ml (6.28-9.12) VS5.96ng/ml(4.87-7.99)], the difference reaches the significance of statistics (P＜0.01). the levelof serm interleukin-6was significantly higher in patients with CHD than in thecontrol group [(72.57±13.15)pg/ml VS(38.83±9.77) pg/ml].2. Serum A-FABP levelin multi-[9.33（8.04-11.09）ng/ml]and double-vessel lesions group [8.22（7.24-9.07）ng/ml] were significantly higher than a single-vessel lesion[6.61（5.62-7.59）ng/ml]and the control group[5.96（4.87-7.99）ng/ml], the difference reaches the significance of statistics (P <0.05). Serum interleukin-6grew with the increasing of coronarylesions;Serum IL-6level in multi-vessel lesions group [（83.73±10.93）pg/ml]wassignificantly higher than double-vessel lesions[（73.44±10.28）pg/ml] and thedouble-vessel lesions was significantly higher than single vessel lesion[（64.89±11.20）pg/ml] and the single vessel lesion was significantly higher thancontrol group[(38.83±9.77)pg/ml], the difference reaches the significance ofstatistics (P <0.05).3.Serum A-FABP level in AMI[7.33（5.66-10.59）ng/ml]、UAP[8.04（6.76-9.07）ng/ml]、SAP[7.42（6.35-8.97）ng/ml] were significantly higherthan control group[5.96（4.87-7.99）ng/ml], but there was no significance of statisticsbetween them（P＞0.05）. Serum IL-6level in AMI[(79.49±11.91)pg/ml],UAP[(70.20±11.27) pg/ml],SAP [(68.48±14.25) pg/ml]were significantly higher thancontrol group[(38.83±9.77) pg/ml]（P＜0.01）; AMI group were significantly higherthan SAP and UAP group（P＜0.05）.4. Serum A-FABP level in severe diseasegroup,moderate lesions group,mild disease group were10.07（8.13-11.63）ng/ml,7.94（7.20-8.96）ng/ml,6.09（5.25-7.24）ng/ml respectively. Serum IL-6level in severedisease group,moderate lesions group,mild disease group were(85.49±10.91)pg/ml,(70.77±8.03)pg/ml,(60.80±8.09)pg/ml respectively. Serum A-FABP level and IL-6level rises as the aggravating of coronary lesions, the difference reaches thesignificance of statistics (P <0.01).5. Serum A-FABP were positive correlated withIL-6, hs-CRP and total cholesterol. Serum A-FABP level were negative correlatedwith high density lipoprotein cholesterol levels (P <0.05).6. Logistic regressionsuggest that serum A-FABP level and coronary heart disease were closely related.Conclusions:1.Serum A-FABP was correlated with the occurrence and pathological damage of thecoronary heart disease.2. Serum A-FABP was correlated with the lipid levels and itmay affect the coronary arteries through the lipid disorders.3.Serum A-FABP wascorrelated with the inflammatory mediators such as IL-6and hs-CRP. It mayinfluence the stability of coronary artery plaque through the inflammatoryreaction.4.Serum A-FABP may be one of the independent risk factors of coronary heart disease.