Abnormal Neurite Orientation Dispersion And Density Of White Matter In Children Suffer From Primary Nocturnal Enuresis

Purpose:To evaluate diffusional changes of the white matter in children with primary nocturnal enuresis(PNE)by neurite rientation dispersion and density imaging(NODDI).Methods:Forty PNE children(9.3 to 13.0 years,with a median age of 11.2 years)and Forty health controls(9.2 to 13.3 years,with a median age of 10.9 years)were enrolled in this study.Diffusion MRI data for NODDI were acquired in a resting state.The orientation dispersion index(ODI)and intra-cellular volume fraction(Vinc)were calculated.Tract-based spatial statistics(TBSS)analyses of WM tracts were performed with ODI and Vinc in PNE children and controls then.Result:Children with PNE had lower ODI in WM fiber tracts of bilateral suprerior longitudinal fasciculus(SLF),higher ODI in bilateral internal capsule(IC)and right anterior thalamic radiations(ATR)than that of controls(P<0.05,TFCE corrected),PNE children also had lower Vinc in bilateral internal capsule(IC)and cingulum,higher Vinc in bilateral SLF(P<0.05,TFCE corrected).Conclusion: Abnormalities of neurite orientation dispersion and density in WM fiber tracts of SLF,IC,ATR and cingulum are likely to be involved in the onset and progression of PNE in children.