| Objective: To investigate the relationship between fraction excretion of uric acid and severity of tubulointerstitial damage in patients with primary kidney disease in Liaoning.Methods: Retrospective analysis of 889 cases of renal biopsy confirmed by renal biopsy in the First Affiliated Hospital of China Medical University in Liaoning Province as pathological and clinical data of patients with primary glomerular disease,according to serum uric acid male > 420 umol / L,female > 360 umol / L,divided into high uric acid In the normal group and the normal uric acid group,the clinical and pathological parameters were compared between the two groups.The uric acid excretion fraction(FEua)was calculated by blood uric acid(SUa),uric acid(UUr),serum creatinine(SCr),and urine creatinine(UCr).Because of the different scoring methods of tubulointerstitial,patients were divided into Ig A nephropathy group and non-Ig A nephropathy group,and the relationship between uric acid excretion score and severity of tubulointerstitial damage in primary kidney disease was discussed.Results: 1.A total of 889 patients were enrolled,560(62.99%)in the normal uric acid group,329(37.01%)in the hyperuricemia group,and 60(6.76%)in the recurrent hyperuricemia group.Primary hyperuricemia Of the 269 patients(30.25%),241 patients(27.11%)had reduced uric acid excretion,24 patients(2.70%)had mixed type,and 4patients(0.45%)had increased type in primary hyperuricemia.The proportion of hyperuricemia complicated with hypertension(53.05%)was significantly higher than that of normal uric acid group(37.61%),the difference was statistically significant(P<0.05).The hyperuricemia group complicated with massive urinary proteinuria.The proportion of(>3.5g)was lower than that of the normal uric acid group(49.37%),and the difference was statistically significant(P<0.05).There was no significant difference in the proportion of diabetes mellitus between the two groups.2.Compared with the hyperuricemia group,24-hour urine protein,platelets,serum albumin,low-density lipoprotein,high-density lipoprotein,total cholesterol,immunoglobulin A,immunoglobulin G,e GFR,The difference between BMI was statistically significant(P<0.05).There was a correlation between serum uric acid level and renal tubulointerstitial damage(P<0.05 in both Ig A and non-Ig A groups),and the difference was statistically significant.The hyperuricemia group was divided into three groups according to the fraction excretion of uric acid,which were fraction excretion of uric acid(<7%),mixed type(7%-12%),and increased production(>12%).There were significant differences in hemoglobin,urea nitrogen,cystatin C,uric acid and e GFR(P<0.05).3.The fraction excretion of uric acid of Ig A group and non-Ig A group were correlated with the degree of tubulointerstitial damage(P<0.001).The fraction excretion of uric acid in the Ig A group was 0,1,2 in the tubulointerstitial lesions,respectively,5.03± 2.15,6.29 ±2.86,8.40 ± 5.39,and the fraction excretion of uric acid in the non-Ig A group was 0,1,2,3 in the tubulointerstitial lesions were 5.08±3.22,5.90±3.83,9.20±5.77,and 18.40 ± 12.79,respectively.Non-Ig A group: the degree of renal tubulointerstitial damage was positively correlated with serum creatinine,fraction excretion of uric acid,blood uric acid(r=0.4654,P<0.05;r=0.2471,P<0.05;r=0.1144,P<0.05),The difference was statistically significant.Ig A group: the degree of tubulointerstitial damage was positively correlated with serum creatinine,blood uric acid,and fraction excretion of uric acid(r=0.6434,P<0.05;r=0.3395,P<0.05;r=0.3057,P<0.05),and uric acid There was a negative correlation(r=-0.2245,P<0.05),and the difference was statistically significant.Conclusion: The fraction excretion of uric acid of primary nephropathy is positively correlated with the degree of tubulointerstitial damage.The fraction excretion of uric acid increases with the severity of tubulointerstitial damage.The fraction excretion of uric acid may be a non-invasive indicator for assessing and monitoring the extent of tubular damage. |
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