The Association Between Metabolic Syndrome And Ovarian Cancer In Elderly Female Patients

Objective: Studies have shown a link between metabolic syndrome and malignancy,but such studies are less common and the relationship between them is still unclear.This paper aims to explore the relationship of metabolic syndrome and ovarian cancer in the elderly and help to diagnose and prevent the ovarian cancer through the case-control method.Methods: Retrospective analysis was used,and the clinical data of 61 elderly patients with the senile ovarian cancer and 67 elderly patients with benign ovarian tumor who were treated surgically in the First Hospital of China Medical University from October 2014 to September 2017 were selected as the objects of study.Based on the medical history,biochemical tests and other data,T-test and ? 2 test were used to compare baseline differences.Pearson analysis was used for the correlation analysis.Logistic regression model was used to analyze independent risk factors for the incidence of ovarian cancer in the elderly in the related factors of metabolic syndrome.The ROC curve was plotted for the independent risk factors obtained from the model,and the diagnostic value of independent risk factors for ovarian cancer was evaluated by the area under the curve(AUC).Results:1.By comparing the baseline between the two groups,it was found that the levels of fasting blood glucose and D-dimer in the malignant group were significantly higher than those in the benign group,and the high-density lipoprotein cholesterol(HDL)and total cholesterol(TC)were lower than that in the benign group.The difference was statistically significant(P<0.05).There was no significant difference in age of onset,pregnancy,parity,menarche age,body mass index(BMI),systolic blood pressure,diastolic blood pressure,low-density lipoprotein cholesterol(LDL)and triglyceride(TG)(P>0.05).2.There were more patients with metabolic syndrome and hyperglycemia in the malignant group than that in the benign group,which was positively correlated with ovarian cancer.3.Compared with benign group,the patients with metabolic syndrome had4.043-fold higher risk of ovarian cancer than the non-metabolic syndrome patients(OR=4.043,95%,CI: 1.371-11.926,P<0.05),and the prevalence rate rose with age.4.Logistic regression analysis found that the hyperglycemia,high-density lipoprotein(HDL),total cholesterol(TC),D-dimer levels were risk factors for ovarian cancer,while the hyperglycemia and D-dimer level were the independent risk factors for ovarian cancer.5.The area under the ROC curve of D-dimer was 0.830,and the area under the ROC curve of blood glucose was 0.550.The diagnostic value of D-dimer for ovarian cancer is higher than that for blood glucose.Conclusion:1.Metabolic syndrome is a risk factor for the onset of ovarian cancer,and the prevalence increases with age.2.Hyperglycemia and D-dimer levels are independent risk factors for the onset of ovarian cancer.3.The diagnostic value of D-dimer is superior to that of blood glucose,so it can be used as an auxiliary diagnosis indicator of ovarian cancer.Combined with other related laboratory tests and imageological examinations,the detection rate of ovarian cancer can be increased,which is conducive to the prevention,early detection and treatment of ovarian cancer.