A Correlation Research On TCM Constitution And Ischemic Stroke Recurrence-Nested Case-Control Study

Objectives The nested case-control study was used to observe and analyze the factors influencing the recurrence of ischemic stroke,and to explore the relationship between TCM constitutional status and recurrence in patients which ischemic stroke,so as to provide more effective reference basis for the prediction of the recurrence of ischemic stroke patients and the "Preventive recurrence after disease" from the perspective of the constitution of Chinese medicine.Methods A nested case-control study was conducted in which 339 patients with ischemic stroke were enrolled in the study cohort for 1 year follow-up.37 patients who relapsed during the follow-up period served as the relapse group,148 patients without recurrence were matched as control group at the ratio of 1:4.The age,sex,hypertention,hyperlipidemia,diabetes mellitus,hyperhomocysteinemia,coronary heart disease,acute stroke treatment with low molecular weight heparin test(TOAST),National Institutes of Health Stroke Scale(NIHSS),whether the first onset,time of taking Chinese medicine decoction,time of rehabilitation and constitution of TCM between the two groups were statistically compared.Logistic regression model was used to analyze the variables with statistical significance in the above univariate analysis.Results In this study,there were 37 cases in the relapse group and 148 cases in the control group.There were no statistically significant differences in age,gender,hypertension,hyperlipidemia,mellitus diabetes,hyperhomocysteinemia,coronary heart disease,NIHSS score and whether the first onset between the relapse group and the control group(P>0.05)after test.The difference of TOAST classification between the two groups was statistically signifiant(P<0.05).The LAA type in the relapse group was more than that in the control group(P<0.05).In term of TCM constitution,the Qi deficiency type in the relapse group was more than that in the control group(P<0.05).The phlegm-dampness type in control group was more than that in the relapse group(P< 0.05).In the overall TCM constitution state,the highest proportion of Qi deficiency and Qi deficiency in the relapse group was 78.38%,In the control group,the highest proportion of phlegm-dampness was79.73%,In the single TCM constitution state distribution,the proportion of Qi deficiency was the highest and Qi deficiency in the relapse group was 16.22%,and the proportion of phlegm-dampness in the control group was the highest,in the control group was 6.76%.The proportion of Qi deficiency+phlegm-dampness in both groups was 32.43% and 33.78%,respectively.The proportions of Qi deficiency+blood stasis+phlegm-dampness in both groups was 10.81% and 4.73%,respectively.Logistic regression model analysis showed that LAA type in TOAST classification and Qi deficiency in TCM constitution were risk factors for recurrence of ischemic stroke.Conclusions The specific TCM constitution is correlated with the recurrence of ischemic stroke.Among them,the recurrence rate of Qi deficiency is the highest,and Qi deficiency is a risk factor for the recurrence of ischemic stroke.Figure 3;Table 10;Reference 104...