Clinical Observation Of Shengmaisan Combined With Endocrine Terapy For Treatment Of Advanced Prostate Cancer With Deficiency Of Both Qi And Yin

Objective: To explore the clinical efficacy of Shengmai san combined with endocrine therapy in the treatment of advanced prostate cancer with deficiency of both Qi and Yin,to provide clinical basis for the treatment of advanced prostate cancer with deficiency of both Qi and Yin,and to seek effective treatment for advanced prostate cancer patients with deficiency of both Qi and Yin.Methods: Eighty patients who met the research criteria were randomly divided into two groups: the treatment group of Western medicine(control group)and the treatment group of integrated traditional Chinese and Western medicine(treatment group).The control group was treated with endocrine therapy alone,and the treatment group was treated with Shengmai powder.The changes of solid tumor size,TCM syndrome score,KPS score and related tumor markers were observed before and after treatment to evaluate the effect of the two treatment schemes.Results:1.In terms of the efficacy of solid tumor remission,the effective rate of the tumor in the treatment group was 32.5%,and the effective rate in the control group was 22.5%.There was no significant difference in the efficacy of the solid tumors between the two groups(P>0.05).However,the treatment group was more effective than the control group.2.In terms of KPS score,the KPS scores of the two groups were increased after treatment.The KPS score and efficacy of the treatment group were higher than the control group,and the difference was statistically significant(P<0.05).3.In the TCM syndrome score,the TCM syndrome scores of the two groups were improved after treatment,and the TCM syndrome scores of the treatment group were better than the control group.The difference between the two groups was statistically significant(P<0.05).In terms of the efficacy of single syndrome scores,the treatment group was superior to the control groupin the relief of dysuria,hematuria,urinary frequency,dysuria,night sweats and tongue pulse after treatment.The difference between the two groups was statistically significant(P< 0.05).4.In terms of tumor markers,the PSA levels of the two groups were improved after treatment.The PSA level of the treatment group was better than that of the control group after treatment.The difference of PSA levels between the two groups was statistically significant(P<0.05).Conclusions:Shengmai san combined with endocrine therapy for patients with advanced Qi and Yin deficiency type prostate cancer can effectively inhibit the rise of serum PSA,reduce clinical symptoms such as dysuria,hematuria,urinary frequency,dysuria,night sweats,improve patients' KPS score,and Improve the quality of life of patients.