Correlation Between Benign Paroxysmal Positional Vertigo And Seasonal Changes Of Vitamin D

Objective: Benign paroxysmal positional vertigo(BPPV)is a peripheral vestibular disease characterized by recurrent episodes of transient dizziness and characteristic nystagmus induced by changes in head position relative to gravity.At present,many scholars have found that the reduction of vitamin D may be closely related to the onset and recurrence of BPPV.In addition,the content of vitamin D in the human body is affected by seasonal factors.If there is a relationship between BPPV and vitamin D levels,the incidence of BPPV will also change seasonally.Methods: A systematic review(a total of 48 patients with BPPV admitted to our hospital from 2016-01-01 to 2018-12-31)was conducted to analyze the number of patients with BPPV and the differences in serum calcium between each quarter.Results: There were 48 patients with BPPV diagnosed between 2016-01-01 and 2018-12-31.There was no significant difference in the number of patients between the two groups during the quarter by Kruskal-Wallis H test(P=0.056,P>0.01).But the line chart of the number of patients within 12 months showed an increasing trend in winter,and Pearson correlation analysis showed a significant correlation between the number of patients and the month.In addition,this study showed that there was no significant difference in serum calcium content between different quarters(P=0.373,P>0.01).Conclusion: The incidence of BPPV has seasonal changes,which may be related to the changing pattern of vitamin D.Vitamin D acts directly on the endolymph to affect otolith formation and metabolism.