Correlation Between Intestinal Flora And Papillary Thyroid Carcinoma

Objective:This study was designed to investigate the composition and distribution of intestinal flora in patients with papillary thyroid carcinoma.To compare the difference between thyroid papillary carcinoma and healthy human intestinal flora,in order to find new ideas for the screening,diagnosis and treatment of papillary thyroid carcinoma.Methods: Persons who underwent gland surgery at the People's Hospital of Hebei Province from August 2018 to December 2018 and those who were routinely examined in the outpatient clinic were selected.There were 11 healthy control,8 thyroid papillary carcinoma patients,and 2 thyroid cancer patients with Hashimoto's thyroiditis.The fecal DNA was extracted separately and the bacterial 16 SrDNA V4 fragment was amplified.The information is obtained by means of polymer sequencing,and the species information is determined by checking with the database to analyze the species structure and abundance of the intestinal flora.Results: The structure and abundance analysis of intestinal flora showed that there was no significant difference in the bacterial structure and abundance between the healthy control group and the papillary thyroid carcinoma group.However,there are certain differences in biomarkers.The biomarkers of the healthy control group were Alloprevotella and Enterobacter;the biomarkers of the papillary thyroid carcinoma group were Ruminococcaceae and Lac_KF843559_g.Conclusions:1.The thyroid papillary carcinoma group and the healthy control group have similar colony structure at the high abundance level,that is,Firmicutes,Bacteroidetes,Proteobacteria and Actinobacteria;but in the low-abundance level,there are certain differences in the composition of the Family level of the subject.2.Thepapillary thyroid carcinoma group's biomarkers are Rum_HQ748384_g and Lac_KF843559_g.;healthy control has biomarkers of Alloprevotella and Enterobacter.3.The abundance of Ruminococcaceae and Lachnospiraceae may be related to the occurrence and development of papillary thyroid carcinoma.