The Dynamic Characteristics Of Regional Cerebral Activity In Stroke Patients

Objective:To investigate the longitudinal difference brain regions and their dynamic evolution patterns in patients with subcortical cerebral infarction,and to explore whether the dynamically altered regional indexes were associated with clinical behavior in stroke patients.Materials and Methods:Twenty-two patients enrolled with subcortical cerebral infarction were longitudinally examined at four time points within six months after the onset of the stroke.A 3D high-resolution T1 WI anatomical image acquisition and a resting-state functional magnetic resonance scan were performed using a 3.0T magnetic resonance scanner(GE Discovery MR750 magnetic resonance instrument).Then,23 healthy volunteers with gender and age matched were enrolled as the control group.The rs-fMRI states was preprocessed to obtain the whole brain ReHo image and ALFF image.The generalized linear model was used to calculate the differential brain regions of ReHo and ALFF,and to analysis the dynamic charicteristics of mReHo and mALFF.Finally,associations between these measures and clinical variables were also explored in stroke patients.Result:1.The longitudinal significant regions of ReHo in patients with subcortical cerebral infarction are bilateral preceneus and contralesional middle occipital gyrus(MOG).The mReHo value of bilateral preceneus increased initially as compared controls,then gradually decreased with no significance(P>0.05),remaining lower leval for weeks and silightly increased,and finally lower than the control group,the difference was not statistically significant(P>0.05).The mReHo of contralesional middle occipital gyrus was lower than the control group,and the difference was statistically significant(P<0.05),then the mReHo increased remaining for a stable level,finally lower than the control group,and that was not significant(P>0.05).2.The longitudinal significant regions of ALFF in patients with subcortical cerebral infarction are in the bilateral precuneus and ipsilesional inferior frontal gyrus(IFG).The mALFF of the bilateral precuneus was lower than controls,then continued to decrease but slightly increased finally,lower than controls finally,and the difference was statistically significant(P<0.05).In contrast,the trend of mALFF of RIFG was increased earlier than the controls,then decreased slightly,remaining for a lower and stable leval as compared controls,but There was no significant difference between the two groups(P>0.05).3.The mALFF of IFG has a certain correlation with verbal short-term memory,and the early mALFF value was positively correlated with the verbal short-term memory of chronic stroke patients.Conclusion:This study explored the longitudinal difference brain regions and their dynamic evolution patterns in patients with subcortical cerebral infarction.The significant brain region of ReHo were bilateral precuneus and contralesional MOG,and the ALFF of differential brain region were bilateral precuneus and the ipsilesional IFG.The mALFF value of the ipsilesional IFG has a certain correlation with the recovery of verbal short-term memory and cognitive function in stroke patients,and may be a potential predictor of verbal short-term memory function prognosis.Additionally,The longitudinally different brain regions of the local brain activity can provide new ideas for future research about brain function and structure in stroke patients.