Functional Magnetic Resonance Imaging(fMRI)Explore The Cerebral Function And Structure Changes Of The Depression First-degree Relatives

Chapter one The fMRI Study on the ALFF values of the Brain in Major Disorder Depression and their First-level RelativesObjective To study characteristics and differences of the amplitude of low-frequency fluctuation(ALFF)and the fractional ALFF(fALFF)of the major disorder depression(MDD)and their first-degree relatives in the resting state by functional magnetic resonance imaging(fMRI),in order to understand the early brain function in patients with MDD.Methods The experiments were performed by 3.0 T fMRI in 10 patients with MDD(the depression group),10 first-degree relatives of MDD(the first-degree relatives group)and 10 healthy volunteers(the control group).An statistics analysis of ALFF and fALFF were performed subsequently.Results The ALFF and fALFF values measured in left cerebellum,left precuneus and left medial prefrontal cortex of MDD group were significantly lower than those of the first-degree relatives group(P<0.05).The ALFF values measured in right posterior cingulate cortex and right inferior parietal lobule of MDD group were significantly lower than those of the first-degree relatives group(P<0.05).The ALFF and fALFF values measured in left cerebellum,left precuneus and right inferior parietal lobule of MDD group were significantly lower than those of the control group(P<0.05).The ALFF values measured in left inferior parietal lobule of the first-degree relatives group were significantly lower than those of the control group(P<0.05).The fALFF values measured in right cingulate cortex and medial prefrontal cortex of MDD group were significantly lower than those of the control group(P<0.05).Conclusion With the widespread ALFF,fALFF abnormal of brain in MDD and first-degree relatives of MDD measured,we can get a hypothesis that these abnormals may be associated with cognitive network disorders and emotional distress in MDD.Chapter two The fMRI Study on the ReHo Values of the Brain in Major Disorder Depression and Their First-level RelativesObjective To study characteristics and differences of the regional homogeneity(ReHo)of the major disorder depression(MDD)and their first-degree relativesin the resting state by functional magnetic resonance imaging(fMRI),in order to understand the early changes of the brain function in patients with MDD.Methods The experiments were performed by 3.0 T fMRI in 15 patients with MDD(the depression group),15 first-degree relatives of MDD(the first-degree relatives group)and 15 healthy volunteers(the control group).A statistics analysis of ReHo was performed subsequently.Results The ReHo values measured in right middle frontal gyrus,right precentral gyrus,right superior frontal gyrus,right anterior cingulate cortex,right insular,left putamen,left superior temporal gyrus,left middle temporal gyrus,left dorsal cingulate cortex of MDD group were significantly lower than those of the first-degree relatives group(P<0.05).The ReHo values measured in left postcentral gyrus,left superior temporal gyrus,left middle temporal gyrus,left inferior frontal gyrus,left orbitofrontal cortex,left dorsal cingulate cortex,right precentral gyrus,right medial prefrontal cortex,right superior frontal gyrus,the middle frontal gyrus,the anterior cingulate cortex,right insular of MDD group were significantly lower than those of the control group(P<0.05).The ReHo values measured in left anterior lobe of cerebellum,left middle temporal gyrus,left inferior frontal gyrus,left orbitofrontal cortex,left superior frontal gyrus,left dorsal cingulate cortex,left insular,right middle frontal gyrus,right anterior cingulate cortex of the first-degree relatives group were significantly lower than those of the control group(P<0.05).Conclusion With the widespread ReHo abnormal of brain in MDD and first-degree relatives measured,we can get a hypothesis that these abnormalities may be associated with cognitive network disorders and emotional distress in MDD.