| ObjectiveMuch is known about body composition and type 2 diabetes risk but less about body function such as strength.We assessed whether hand-grip strength have relationship with type 2 diabetes in a large adult population,so as to offer evidences for early prevention of type 2 diabetes.MethodsThe cohort study data were derived from Tianjin chronic low-grade systemic inflammation and health Cohort Study.The study included a total of 38,483 regular physical examinations including blood glucose testing in Tianjin during 2013-2018,and a total of 22,143 people were involved in the final analysis after excluded the unqualified population.Before participating,all participants signed an informed consent form and volunteered to participate in this cohort study.We collect data as questionnaires,physical and laboratory exams for later statistical analysis.The semi-quantitative food frequency questionnaire of the reliability and validity test was used to assess the dietary intake of the subjects,and the blood glucose test was used to diagnose type 2 diabetes.Divide the grip strength into quartiles.Grip strength indicators include absolute grip strength and relative grip strength.We fit variance and logistic regression model to examine the differences of basic characteristics between populations with or without type 2 diabetes groups and with different absolute grip strength quartiles,and relative grip strength quartiles.The prevalence of Type 2 diabetes was used as dependent variables,and the quartiles of absolute grip strength and relative grip strength were independent variables.We use multiple cox regression analysis to conduct the relationship between the size of grip strength and type 2 diabetes.We fit multivariate cox regression stratified by gender to examine the association between the size of grip strength and type 2 diabetes in men and women respectively.ResultsIn the present study,the incidence of type 2 diabetes in overall participants was 3.11%;in men was 4.20%;in women was 1.85%.The incidence of diabetes in men was higher than that in women(P <0.001).In the comparison of the basic characteristics of the population,the total population between with or without type 2 diabetes and the absolute grip force quartile and the relative grip force quartile group age,gender,waist circumference,blood pressure,BMI,biochemistry,smoking,drinking and dietary intake were statistically significant differences(P < 0.05);similar results were observed in the gender stratification analysis.In multiple COX regression model analysis,after adjusting potentially confounding factors,the hazard ratio(95% confidence interval)of type 2 diabetes across quartile of absolute grip(95% confidence interval)was 1.00,1.06(0.86,1.31),0.93(0.75,1.16),0.97(0.78,1.21)(trend P = 0.54)in overall participants;1.00,1.10(0.86,1.41),0.89(0.68,1.15),0.96(0.74,1.25)(trend P = 0.44)in men;and 1.00,0.93(0.62,1.39),1.03(0.69,1.53),0.97(0.63,1.49)(trend P = 0.98)in women.We find no statistically significant differences in any population.In the multiple adjustment(model 3),the relative grip strength quartiles group was negatively correlated with the occurrence of T2DM(trend P <0.001).Compared with the "minimum quartile relative grip strength group".the “highest quartile relative grip strength group” has a 0.63-fold lower risk of developing T2 DM in overall participants,which is also observed in gender stratification.However,when BMI is adjusted based on multiple adjustment(model 3),No statistically significant differences were observed in any population,which is also observed in gender stratification.ConclusionsHigher relative grip strength was negatively associated with T2 DM in a large adult population.BMI is more closely related to T2 DM than grip strength.,which may be an intermediate variable between grip strength and T2 DM.Therefore,it is necessary not only to enhance the relative grip strength,but also to properly reduce the BMI,thereby preventing the occurrence and development of T2 DM. |
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