The Comparative Study Of Digonow Or Capecitabine Combined With Oxaliplatin Into First-line Treatment The Curative Effect Of Middle-late Gastric Cancer

Objective:In addition to surgery,postoperative adjuvant therapy is very important to the treatment of advanced gastric cancer.Fluorouracil is a commonly used drug for chemother-apy of gastric cancer.Tipico and capecitabine are often preferred as adjuvant chemotherapy for advanced gastric cancer because of their simple oral administration,low toxic and side effects,and strong antitumor potency.Especially in the late stage of gastric cancer and elder-ly patients with a single medication.Although oxaliplatin is used in multiple combination chemotherapy regimens,the combination of oxaliplatin and oral fluorouracil such as oral tegafur or capecitabine has not been determined in the treatment of PFS,OS,and side effects of advanced gastric cancer.Comparison of tegafur+oxaliplatin and adverse reactions in pa-tients with advanced or capecitabine+oxaliplatin in the treatment of gastric cancer in.Methods:All patients were enrolled in patients who were diagnosed with stage II-IV gastric cancer by pathology or cytology from Feburary 2014 to December 2016 in the gas-trointestinal surgery or oncology department of the Sichuan Provincial People's Hospital for oral fluorouracil drugs.The differences were divided into group A:tegafur+oxaliplatin,te-pio capsule 60 mg,bid,dl-14;oxaliplatin 130 mg/m2,dl,for a period of 3 weeks.Group B:capecitabine+oxaliplatin,capecitabine tablets 1500 mg,bid,dl-14;oxaliplatin 130 mg/m~2,dl,3 weeks for one cycle.After the completion of 2 cycles of chemotherapy,the patient's PFS,OS,and toxic and side effects were evaluated according to the evaluation criteria.The objective effectiveness(ORR)and disease control rate(DCR)were compared.Statistical analysis was performed using softwareResults:The median PFS was 9.4 months for the A group and 10.1 months for the B group(P=0.634),the median OS of group A and B were 24.8 months and 22.6 months re-spectively(P=0.723).Both the PFS and OS difference didn't reach statistical significance.Theobjective effective rates(ORR)of group A and group B were 36.5%and 33.6%respec-tively(P=0.887);the disease control rate(DCR)was 61.0%,60.0%(P=0.898);There was no significant difference in the objective effective rate(ORR)and disease control rate(DCR)between the two groups(P>0.05).Two groups of anemia,fatigue,nausea and vomiting,liver function injury and peripheral neuritis were compared,the difference was not statistically significant(P>0.05).Diarrhea in group A and B was 22.0%(35 cases),32.8%(41cases)(P=0.041),hand foot syndrome was 20.7%(33cases),29.6%(37 cases)(P=0.052),The inci-dence of diarrhea and hand foot syndrome in group B was higher than that in group A,but no serious side effects occurred in both groups.Conclusion:The effect and safety of two treatment group with advanced gastric cancer were quite good,and have certain clinical practicality and value.Tegafur+oxaliplatin group diarrhea and hand foot syndrome incidence is lower than that of capecitabine and oxaliplatin group,but there was a slightly better therapeutic effect and should be individualized.