Clinical Analysis Of Necrotizing Enterocolitis In 104 Premature Neonates:the Correlation Factors Of Incidence And Progression

Objective To explore the correlation factors for the development and progression of neonatal necrotizing enterocolitis(NEC),in an effort to provide clinical evidence for the treatment,prevention and prognosis improvement of NEC.Methods Retrospective analysis was performed on clinical data collected from premature infants diagnosed with NEC in Department of Neonatal Intensive Care Unit,Shanghai Children's Medical Center from January 2004 to June 2015.The observational indicators included 8 perinatal factors,general conditions,Bell's type and prognosis,14 related complications,feeding status,and the use of oral probiotics,RBC transfusion,oxygen inhalation,and vasoactive drugs.Grouping criteria:(1)Based on the general conditions of the patients in the NEC group,non-NEC premature patients with complete perinatal data were randomly assigned to the control group,for comparison of the pathogenic factors with the NEC group.(2)Based on the Bell's staging criteria,the NEC group was further divided into the stage I subgroup versus the stage II/II subgroup for comparative study.Using the SPSS19.0 software,data was analyzed by the methods including t-test,chi-square test,Fisher's exact test and multivariate Logistic regression analysis.Results The incidence of NEC among the 104 premature infants presented a tendency toward increasing from 2004 to 2014.The correlation factors for NEC development include NRDS,neonatal anemia,neonatal septicemia,oxygen inhalation,and use of vasoactive drugs;multivariate analysis indicated NRDS and use of vasoactive drugs as risk factors for NEC development.The correlation factors for NEC progression include neonatal hyperbilirubinemia,neonatal septicemia,and use of vasoactive drugs;multivariate analysis indicated neonatal hyperbilirubinemia as a protective factor and neonatal septicemia as a risk factor for NEC progression.Conclusion NRDS is a risk factor for NEC development.Neonatal septicemia is a risk factor for NEC progression.Neonatal hyperbilirubinemia is a protective factor for NEC progression.