Correlation Analysis Between The Degree Of Enhancement Of CT And The Risk Of Ki-67 Proliferation Index And Gastrointestinal Stromal Tumors

Objective: Retrospective analysis of 72 cases of gastrointestinal stromal tumor patients with preoperative intensive CT enhancement and postoperative imunohistochemistry ki-67 proliferation index related to the risk of disease,and analysis of CT enhancement degree and ki-67 The proliferation index is related.Methods: Selected from December 2011 to January 2019 in our hospital,after surgical treatment,preoperative CT was initially diagnosed as gastrointestinal stromal tumor,postoperative immunohistochemical diagnosis of primary gastrointestinal stromal tumor(GIST)),and exclude patients who may be wild-type GIST and other tumor history as selected cases.According to the 2008 improved NIH risk assessment,the selected cases were divided into four groups: extremely low risk,low risk,moderate risk and severe risk.According to the degree of enhancement of preoperative CT enhancement,Patients with different risk were divided into three groups: mild,moderate and severe.According to the difference of ki-67 proliferation index in postoperative immunohistochemistry,patients with different risk were divided into < 1%,1%-5%(including 1%-5%),> 5% three levels,collate data,tabulate data,apply relevant statistical methods to analyze data,and analyze whether there is statistical significance between the indicators.Results: According to the standard,72 cases were divided into 4 groups according to the risk classification criteria,6 cases with extremely low risk,32 cases with low risk,52.8% for very low and low risk groups,6 cases with intermediate risk and 28 cases with high risk.The middle-high risk group accounted for 47.2%;according to the degree of enhancement of preoperative enhanced CT,it was divided into 3 groups,15 cases were mildly enhanced,accounting for 20.8%;41 cases were moderate,accounting for 56.9%;and 16 cases were severe,accounting for 22.2%;Chi-square test was used between risk grade and CT enhancement,P=0.369>0.05,the difference was not statistically significant,and there was no significant correlation between risk grading and CT enhancement.According to the postoperative immunohistochemistry,the ki-67 proliferation index was divided into three groups: < 1% of 2 cases,1%-5%(including 1% and 5%)of 43 cases,?5% accounted for 62.5%;> 5 27% of the cases,accounting for 37.5%.The chi-square test was used between the risk grade and the ki-67 proliferation index,P=0.038<0.05,the difference was statistically significant.It was considered that the risk grade was related to the ki-67 proliferation index,and the risk grade was set as the dependent variable.Logistic regression analysis showed that ki-67 was positively correlated with risk grade,and the higher the ki-67 proliferation index,the higher the risk.The chi-square test was used between CT enhancement and ki-67 proliferation index,P=0.163>0.05.The difference was not statistically significant.It was considered that there was no significant correlation between CT enhancement and ki-67 proliferation index.Conclusions: A retrospective analysis showed that the ki-67 proliferation index was positively correlated with risk grade in postoperative immunohistochemistry of gastrointestinal stromal tumors,while the degree of enhancement CT and risk grading and ki-67 proliferation index were not.