Gastrointestinal Stromal Tumors: Risk Degree And MSCT Anifestations, Immunohistochemistry Research

Objective: Through the gastrointestinal stromal tumor (GIST) of the MSCTimaging features and immunohistochemistry characters and to explore the correlationbetween the two and tumor risk degree. To help correct preoperative assessment oftumor risk and evaluate the value of immunohistochemistry for tumor risk assessment.Materials and methods: Retrospective analysis and collection at the same timehistopathological examination and immunohistochemistry in48cases of GIST MSCTdata. Through the results of immunohistochemistry of tumorthe tumor site, tumor size,morphology,surrounding violations calcification,density,growth pattem,aggrandizement,tumor or vascular to evaluate the situation of the tumor. The above data will be groupedaccording to the risk degree. Analyze the statistically significant correlation between thevarious manifestations of MSCT tumors, immunohistochemistry and risk degree (lowrisk, moderate risk, high risk). Which risk degree based on risk degree methoddeveloped on2008the U. S. National Institutes of Health (Table2). Using SPSS16.0soflware package for statistical analysis, tumor high risk and low risk of patient sex,endangering the tumor site, tumor size, morphology, density, growth pattem,aggrandizement, peritumoral or intratumoral vessels, immunohistochemical resultsbetween the statistical difference by using chi-square test, to calculate the χ2value,draw the corresponding P values, P <0.05indicatesthe difference was statisticallysignificant. Tumer onset age and CT scan of arterial, venous phase and the delay periodbetween CT value difference with single factor analysis of variance to calculate the value of F, draw the corresponding P values, P <0.05indicatesthe difference wasstatistically significant.Result: The group of48cases,30cases of low risk, moderate in11cases,7casesof high. To observe and analyze MSCT image, the tumor originated in the28cases ofgastric wall,16cases of small intestine,4cases of colorectum. To5cm for the sector,maximum tumor diameter was larger than5cm in26cases,≤5cm in22cases.18casesof tumor morphology rules,30cases of irregular tumor. The tumor cavity shape growthin20cases,12cases with intraluminal growth, mixed growth in16cases: in17cases,31cases of uniform density, uneven density, which shows cystic necrosis in30cases,12cases of surface ulceration, calcification4cases the tumor, the tumor enhanced scanshowed homogeneous enhancement in17cases,31cases showed heterogeneousenhancement.36cases of clear boundry and fat clearance clear, ill-defined, increaseddensity of surrounding fat in12cases,10cases of lymph node metastasis, distantmetastasis occurred in7cases.13cases of visible in tumor, around tumor blood vesselsin14cases. Statistical analysis was performed on the above data, in MSCT imagingfeatures, the tumor site, tumor size, morphology, surrounding violations calcification,density, growth pattem, aggrandizement, tumor or vascular, were associated with therisk of tumors have significant difference, P<0.05. Risk of tumor occurred in theintestinal than occurred in the gastric stromal is higher.The larger the tumor, irregular,external cavity or cavity internal/external growth could prompt high dangerous. Unevendensity inside the tumor appears cystic necrosis, ulcers and tumors were caughtheterogeneous enhancement may indicate cancer risk is high. Tips violations aroundtumors may indicate a high risk of cancer. Found within the tumor or peritumoralvessels may suggest a higher degree of risk. Between tumor calcification and tumor riskhave no exact statistical significance. The various risk degree tumor of CT unenhanced,arterial phase, the venous phase and delayed CT image features had no statisticaldifference, P>0.05. Immunohistochemical examination of44cases positive for CD117,CD34-positive34cases, Ki-67-positive16cases, P-53-positive in13cases. Afterstatistical analysis, between CD117, CD34and tumor risk have no exact statistical significance, P>0.05, Ki-67, P-53between cancer risk and correlation exists, P <0.05,Ki-67, P-53-positive tumors may be prompted to dangerous high.Conclusion:MSCT is an important means to detect gastrointestinal stromal tumors,Though observing the tumor site, tumor size, morphology, surrounding violations,calcification, density, growth pattem, aggrandizement, tumor or vascular, GIST riskdegree can be judgment, and to help correct preoperative assessment of tumor risk,aswell as provide clinicians an important basis for the development and analysis ofprognosis in patients with GIST treatment programs. Immunohistochemistry is a GISTdiagnosis main based, which Ki-67, P-53expression in tumor risk assessment has animportant value.