Analysis Of Coronary Artery Lesions In Patients With Early Acute Coronary Syndrome Complicated With Hyperuricemia

Objective:To study the characteristics of coronary artery lesions in patients with early onset acute coronary syndrome(ACS)accompanied by hyperuricemia(HUA).Methods:From October 2016 to October 2018,208 patients with acute coronary syndrome diagnosed in the People's Hospital of Inner Mongolia Autonomous Region were retrospectively analyzed.The age of the patients was less than 55 years for males and 65 years for females,and the condition of coronary artery lesions was confirmed by coronary intervention.According to the results of uric acid level,105patients were divided into hyperuricemia group and 103 patients in non-hyperuricemia group.To compare the coronary artery lesions.Peripheral venous blood was collected in the morning after admission(12 hours on fasting).Fasting blood glucose,total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL-C)and blood uric acid(BUA)were measured.Coronary artery intervention was performed to determine coronary stenosis.Gensini score was calculated according to coronary stenosis.All the data collected were analyzed by SPSS 22.0statistical software.The measurement data were expressed as?x±s,and the differences between the two groups were compared by independent sample t-test.The use rate of counting data was expressed in the way of comparing the differences between groups by X~2 test.The relationship between Gensini score and hyperuricemia was evaluated by linear regression analysis.The difference was statistically significant with P<0.05.Results:(1)Baseline data analysis:208 patients were compared according to the level of uric acid.There were 105 cases in HUA group,96cases in males and 9 cases in females;103 cases in non-HUA group,93 cases in males and 9 cases in females;there were no significant differences in gender,age,hypertension,smoking history,TC,TG,LDL-C between the two groups(P>0.05).(2)The incidence of single vessel lesions and multiple vessel lesions in HUA group was significantly higher than that in non-HUA group(34.2%vs 49.5%,37.2%vs23.3%,P<0.05),and the incidence of double vessel lesions was not significantly different from that in non-hyperuricemia group(28.6%vs 27.2%,x~2=0.05,P=0.824);there was no statistical significance in the distribution of coronary lesions between the two groups(P>0.05).(3)The number of coronary artery lesions in HUA group was more than that in non-HUA group(2.03+0.87 vs 1.72+0.82,P=0.006).Gensini score was also higher than that in normal uric acid group(61.35+31.53 vs 44.39+28.06),P<0.05).Using Gensini score as dependent variable and uric acid as independent variable,BUA level was linearly correlated with Gensini score.The linear regression equation was y=23.866+0.095x,R~2=0.105.Conclusions:(1)Hyperuricemia is a predisposing factor for early onset of ACS.(2)The lesion range of ACS combined with HUA group was wider than that of non-HUA group.(3)The degree of lesion in ACS combined with HUA group was more serious than that in non-HUA group.