Study On The Correlation Between Ambulatory Arterial Stiffness Index And Target Organ Damage In Patients With Type H Hypertension

Objective:This article focuses on the relationship between plasma homocysteine(Hcy)and dynamic arteriosclerosis index(AASI)and carotid intima-media thickness(IMT)and left ventricular hypertrophy in patients with type H hypertension.Methods:A retrospective study of 255 hypertensive patients hospitalized in the hospital health center ward from January 2016 to December 2018 was conducted according to inclusion criteria.Collect and record 255 people's age,gender,disease course,height,weight,calculate body mass index(BMI)and other data,blood test for biochemical indicators,record plasma homocysteine,fasting blood glucose(FBG),triglyceride(TG),total cholesterol(TC),low density lipoprotein(LDL-C)and high density lipoprotein(HDL-C)and plasma creatinine(Cr)values.Diastolic blood pressure(DBP)and systolic blood pressure(SBP)were collected for 24-hour dynamic blood pressure monitoring,and the dynamic arteriosclerosis index was calculated.The carotid intima-media thickness and heart chamber parameters were measured for each patient and the left ventricular mass index(LVMI)was calculated.According to the blood Hcy level and AASI value,the patients were divided into four groups:group A:high Hcy(HHcy)+normal AASI(HHcy group),group B:abnormal AASI+normal Hcy(abnormal AASI group),group C:HHcy+abnormal AASI group Group D:Normal Hcy+normal AASI(single hypertension group),the correlation between Hcy,AASI and IMT,LVMI was analyzed,and the difference was statistically significant at P<0.05.Results:1.There were no significant differences in age,gender,duration of disease,BMI,FBG,TG,TC,LDL-C,HDL-C and Cr between group A,group B,group C and group D(P>0.05).There were significant differences in 24h mean SBP and 24h mean DBP between group A,group B,group C and group D(P<0.05).2.Comparison of Hcy,AASI and IMT,LVMI:?Group A,group B,and group C were compared with group D:the difference in the values of IMT and LVMI was statistically significant(P<0.05).?Group C was compared with group A:the difference in the values of IMT and LVMI was statistically significant(P<0.05).?Group C was compared with group B:the difference in the values of IMT and LVMI was statistically significant(P<0.05).3.Correlation analysis:Pearson correlation analysis showed that Hcy was positively correlated with IMT and LVMI values(r=0.213,P<0.05;r=0.801,P<0.05;).AASI was positively correlated with IMT and LVMI values(r=0.611,P<0.05;r=0.718,P<0.05;).4.The logistic regression analysis of carotid intima-media thickness(IMT)and its influencing factors were as follows:IMT as the dependent variable,Hcy,AASI,24h average SBP,24h average DBP,daytime mean pulse pressure(PP),daytime average SBP,daytime average DBP,nighttime average SBP,nighttime average DBP and nighttime average PP were independent variables.Logistic regression analysis showed that Hcy and AASI were the influencing factors of IMT.5.The logistic regression analysis of left ventricular mass index(LVMI)and its influencing factors were as follows:LVMI as the dependent variable,Hcy,AASI,24h average SBP,24h average DBP,daytime mean pulse pressure,daytime average SBP,daytime average DBP,nighttime average SBP,nighttime average DBP and nighttime average PP were independent variables.Logistic regression analysis showed that Hcy and AASI were the influencing factors of LVMI.Conclusions:1.Plasma high homocysteine aggravates the damage of target organs in patients based on hypertension.2.Plasma high homocysteine and dynamic arteriosclerosis index may have a synergistic effect on carotid-intimal thickening and left ventricular hypertrophy in patients with H-type hypertension.