Correlation Between Coronary Slow Flow Phenomenon And Cystatin C

Objective: To investigate the factors affecting the occurrence of coronary slow flow phenomenon(CSFP),to observe the influence that cystatin C(Cys C),serum creatinine,uric acid,sex,age,smoking history and other factors have on coronary slow flow phenomenon and their clinical predictive value for the development of coronary slow flow phenomenon,to investigate the correlation between Cystatin C and the coronary slow flow phenomenon,and to study the possible mechanism of Cystatin C affecting the occurrence of coronary slow flow phenomenon.Methods: 389 patients were enrolled into the study with angina symptoms from June 2013 to April 2018 who were treated with concurrent coronary angiography in the Affiliated Hospital of Qingdao University.According to the results of the angiography,they were divided into 3 groups: a total of 138 patients with coronary slow flow were coronary slow flow group,a total of 156 patients with normal angiography were the normal group of angiography,and the angiography suggested that a total of 95 cases of 20%-50% stenosis were listed as the mild stenosis group.We collected the general data and the relevant examination data of the three groups of patients,then determined the concentration of serum inhibitors C,uric acid and creatinine.observe the levels of glutathione C,uric acid and creatinine in the three groups.After removing the extreme values,we took the average of each group,and carried out statistical analysis to see if there is significant difference in the relevant data between the three groups,then search for the correlation between the factors and the occurrence of coronary slow flow phenomenon.Results: 1.The proportion of male in patients with coronary slow flow phenomenon was significantly higher than that in normal group and mild stenosis Group(58.7%),while age(58.986�9.497)and creatinine level(65.647�19.384)were significantly lower than that in normal group(35.90%;61.705�8.562;77.083�65.918,p value is less than 0.05)and mild stenosis group(57.89%;63.537�9.560;79.211�22.644,p value is less than 0.05);The level of Uric Acid(322.485�88.498)and the proportion of smoking history(37.68%)in patients with coronary slow flow phenomenon were significantly higher than that in normal group(0.815�0.172;297.357�82.452;22.44%,p value is less than 0.05)and lower than that in the mild stenosis group((0.881�0.179;325.221�80.180;69.64%,p value is less than 0.05).There was a significant correlation between the 4 factors and the coronary slow flow phenomenon of sex,age,Cystatin C level and creatinine level,in which Cystatin C was an independent risk factor for coronary slow flow phenomenon(OR>1).There was no significant correlation between uric acid,the history of smoking and coronary slow flow phenomenon.2.Among the patients with coronary slow flow,left anterior descending branch(LAD)has the highest proportion(75.36%),the left circumflex artery(LCX)appears second(68.12%),the lowest proportion belongs to right coronary artery(RCA)(23.91%).3.In the CSFP group,cases of CSFP vessel count = 1 were 56(40.58%),cases of CSFP vessel count = 2 were 49(35.51%),and cases of CSFP vessel count = 3 were 33(23.91%).There were no significant differences in gender ratio,age,serum cystatin C level,uric acid level,creatinine level,or proportion of people with smoking history in people with different counts of coronary slow flow affected vessels(P>0.05).Conclusion: 1.Sex of male,lower age and higher Cystatin C level may be risk factors for the occurrence of coronary slow flow phenomenon.The level of serum Cystatin C in patients with coronary slow flow is higher than that in normal group,lower than that of mild stenosis group.The serum Cystatin C level has certain clinical value for the prediction,diagnosis and treatment.2.In patients with slow coronary flow,the left anterior descending branch is most often affected,the left circumlex branch is the second,and the right coronary artery is the least affected.3.There was no significant statistical difference between the general condition and the level of serological examination in patients with different count of vascular involvement.