A Meta-Analysis Of The Relationship Between Atopic Dermatitis And The Expression Of Th17 Cells And IL-17

Objective Atopic dermatitis(AD)is a hereditary chronic recurrent inflammatory skin disease.The etiology and pathogenesis of the disease have not been fully clarified.Relevant studies mainly focus on genetics,environment,immunity and other aspects,and it is found that immune disorder is the important role in the pathogenesis.Currently,there are many case-controlled clinical trials which observes the expression level of Th17 cells and Interleukin(IL)-17 in the patients with atopic dermatitis,but,these studies have significant differences.In order to explore the relationship between atopic dermatitis and the expression of Th17 cells and IL-17,this article applies the method of meta analysis to comprehensively estimate these case-controlled clinical trials.Methods This meta-analysis used computer to search C hinese and English electronic databases such as wanfang database,C hina knowledge network database,Pub Med,etc.,and manually searched library bibliography,and End Note document management software was used to classify and sort the retrieved documents.Strict inclusion and exclusion criteria of literatures were established,and the quality of literatures was evaluated by the newcastle-ottawa quality assessment scale(NOS),so as to screen out high-quality clinical case-control studies on the expression levels o f Th17 cells and serum IL-17 in peripheral blood of patients with atopic dermatitis.A detailed and standardized research feature data table was developed,which was extracted and cross-checked by two researchers.Meta analysis was performed using Review Manager 5.3 software,including analysis of the results of the included studies,heterogeneity analysis and treatment,and risk assessment of publication bias.Results a total of 13 clinical case-control studies were included,including 968 patients with atopic dermatitis and 506 healthy people.There were 6 groups of studies on the expression level of Th17 cells in peripheral blood of patients with atopic dermatitis,and there were 334 patients with atopic dermatitis and 179 healthy people.The results showed that the expression level of Th17 cells in peripheral blood of patients with atopic dermatitis was higher than that of healthy people,and the difference was statistically significant(1.01 [0.46 1.56]).The expression were different,due to different assessment results of disease severity,and the expression may be related to the severity of atopic dermatitis.The differences in observational indicators and regions among different studies may not be the main source of heterogeneity,and more related studies are needed to further confirm.There were 9 groups of studies on the expression level of IL-17 in serum of patients with atopic dermatitis,and there were 778 patients with atopic dermatitis and 397 healthy people.The results showed that the serum l L-17 level in patients with atopic dermatitis was higher than that in healthy people,and the difference was statistically s ignific ant(3.35 [2.08 4.63]).The expression were different,due to different assessment results of disease severity and different age,and the expression may be related to the severity of atopic dermatitis.The differences in diagnostic criteria among different studies are not the main source of heterogeneity.Conclusion The expression levels of Th17 cells and serum IL-17 in peripheral blood of patients with atopic dermatitis is higher than that of healthy people,which may be related to the severity of the disease.