Research On Serum Interleukin-9 And Helicobacter Pylori Infection In Adult Atopic Dermatitis

Object:To detect the levels of serum interleukin-9(IL-9)in patients with atopic dermatitis(AD).14C-urea breath test was determined to study the role of Helicobacter pylori(Hp)infection in the pathogenesis of AD.To study the relationship between Hp infection and levels of serum IL-9.Methods:AD patients and normal healthy controls were selected for the study.The AD group was classified into adult-onset AD and persistent AD according to age of onset.According to the severity of the disease is divided into mild,moderate and severe.The levels of IL-9 and total Ig E were detected by enzyme-linked immunosorbent assay.Hp infection was detected by 14C-urea breath test;the difference of each index in each group and the relation between each index were compared.Results1.40 patients were diagnosed with adult AD,group mild 16 cases,group moderate 21 cases,and group severe 3 cases.The levels of IL-9(12.34±8.36)pg/ml and total Ig E(196.08±289.91)IU/ml in the patient group was higher than that in the healthy group [(8.54±3.56)pg/ml,(24.12±13.54)IU/ml],the difference between the two groups was statistically significant(P<0.05).Patients(twelve,30.0%)who were positive in 14C-urea breath test more than that those were positive in healthy group(three,10.0%),with significant difference(P<0.05).2.There were 25 cases of adult-onset AD patients and 15 cases of persistent AD patients.The clinical manifestations of dry skin?lichenification and hand eczema were more common in the adult-onset AD group.In the persistent AD group not only dry skin,but also eyelid eczema and nose eczema were more common.The average disease duration in patients with persistent AD was(24.60±9.46)years longer than that in patients with adult-onset AD(5.14±6.79)years(P<0.05).No statistically significant difference in the level of severity of disease?IL-9?total Ig E and the positive rate of 14C-urea breath test between the adult-onset AD group and the persistent AD group(P>0.05).3.There was a positive correlation between IL-9 levels and disease duration in AD patients particularly persistent AD patients(P<0.05).There was no statistically significant correlation between IL-9 levels and disease duration in adult-onset AD patients(P>0.05).No statistically significant correlation was found between the level of IL-9 and level of total Ig E;the level of IL-9 and severity of disease in AD group(P>0.05).There was a positive correlation between the total Ig E level and the severity of disease in AD patients(P<0.05).No significant difference was in the level of IL-9 in the AD patients with Hp infection and AD patients without Hp infection(P>0.05).ConclusionsHp infection is associated with the development of AD in adults.IL-9 was involved in the pathogenesis of AD in adults,and played a role in the development of longtime chronic inflammation of adult AD,but its correlation with Hp infection was not significant.