Antibiotic Resistance And Treatment Of Neonatal Sepsis Caused By Escherichia Coli

Objective: To analyze the antibiotic resistance characteristics of Escherichia coli causing neonatal sepsis and to guide the treatment.Methods: The drug sensitivity results of 152 Escherichia coli causing neonatal sepsis from January 2011 to September 2018 were retrospectively analyzed.Results: Positive incidence of the extended spectrum ? lactamase(ESBLs)was 52.0% in early onset sepsis group(EOS),which was higher than 47.8% in late onset sepsis group(LOS),with not difference statistically significant.Preterm group(70.4%)was higher than full-term group(40.8%),with statistically significant difference.No multi drug-resistant Escherichia coli has been tetected during 2011-2014.2 strains,3 strains,1 strains and 3 strains were detected in 2015-2018,respectively.The Escherichia coli has higher resistance to beta lactam antibiotics,especially cephalosporins,and lower resistance to antibiotics containing ?-lactamase inhibitors,carbapenems and aminoglycosides.There is no resistance to amikacin.The strains of ESBLs(+)has higher resistance to multiple antibiotics than the negative one,the difference was statistically significant.Conclusion: The positive incidence of ESBLs is higher in preterm infants.Multi drug-resistant Escherichia coli is increasing.Antibiotics containing ?-lactamase inhibitors and carbapenems should be the first choice in treatment of Escherichia coli sepsis,especially for the ESBLs(+)Escherichia coli.