| Background and purpose:Breast cancer(BC)and gynecological benign and malignant diseases are the most common diseases in women.All of the breast,uterus and ovary are hormone-responsive organs.Studies have shown that BC and gynecological diseases have a certain correlation.This article will explore the incidence of gynecological diseases in BC patients at the initially diagnosed,during chemotherapy and after systemic treatment,and also explore the occurrence of breast nodules in patients with gynecological benign and malignant diseases.Method:1.All the data of female patients with breast disease in the Department of Endocrinology and Breast Surgery,the First Affiliated Hospital of Chongqing Medical University(CQMU)from September 2017 to January2019,who underwent gynecological ultrasound examination,were analyzed.Including 113 patients with benign breast diseases(BBD,meanage: 45.06±10.21),304 cases of initially diagnosed BC patients(mean age:50.23 ± 10.14),579 cases of BC patients during chemotherapy(mean age:48.20 ± 9.33)and 434 cases of BC patients after systemic therapy(mean age: 50.40 ± 9.45).At the same time,10351 healthy people(mean age:45.54±13.24)who underwent gynecological color Doppler examinationat the physical examination center of the First Affiliated Hospital of CQMU were comparatively analyzed.2.All the female patients of gynecological diseases in the Department of Gynecology,the First Affiliated Hospital of CQMU from September2017 to March 2018,who underwent breast color Doppler ultrasound examination,were analyzed.Including 96 cases of patients with uterine malignant disease(mean age: 53.89±10.57),106 cases of patients with ovarian malignant disease(mean age: 54.17 ± 12.73),299 cases of patients with cervical malignant disease(mean age: 49.69 ± 9.98),434 cases of patients with benign uterine disease(mean age: 44.28 ± 9.42),223 cases of patients with benign ovarian patients disease(mean age: 41.99±12.11),108 cases of patients with cervical benign diseases(mean age: 48.66±10.23),and 8469 cases of normal population(mean age: 43.41 ± 14.91)who were also accepted breast color Doppler ultrasound examination in the physical examination center of the First Affiliated Hospital of CQMU were included.The incidence of breast nodules between the above populations was analyzed and compared.Result:1.In the normal physical examination population,the incidence of breast nodules was 17.8%,which was significantly lower than that of patients with uterine malignant diseases(30.2%),cervical malignant diseases(34.7%),benign uterine diseases(46.1%),benign ovarian diseases(36.3%),benign cervical diseases(38.9%),and there was a statistically significant difference(P <0.05).The incidence of breast nodules in ovarian malignant diseases was also higher than that in the normal population without statistically significant.The incidence of breast nodules in benign uterine diseases was higher than that in uterine malignant diseases(46.1% vs 30.2%,P<0.05).The incidence of breast nodules in ovarian benign diseases was higher than that in ovarian malignant diseases(36.3% vs 24.5%,P<0.05).The incidence of breast nodules in benign and malignant cervical diseases was 38.9% and 34.7%,respectively,but there was no statistically significant difference.In uterine malignant diseases,ovarian malignant diseases,and cervical malignant diseases,the incidence of breast nodules of BI-RADS ?4 were10.4%,6.7%,and 6.0%,respectively,compared with that in the normal population(2.3%),with significant statistical differences.In benign uterine diseases,benign ovarian diseases,and benign cervical diseases,the incidence of breast nodules of BI-RADS ?4 was also higher than that of the normal population(11.1%,8.5%,7.4% vs 2.3%),with statisticallysignificant differences.However,there was no statistically significant difference in benign and malignant diseases.2.The incidence of uterine solid masses(considering uterine fibroids or adenomyoma)in the normal population is 22.0%,which was significantly lower than that patients with benign breast disease(31.0%),initially diagnosed BC patients(30.6%),BC patients during chemotherapy(32.6%)and BC patients after systemic therapy(38.5%),the difference was statistically significant.There was no significant difference in the probability of uterine solid occupation among the initially diagnosed breast cancer patients,during chemotherapy patients,after systemic treatment patients and benign breast disease patients.The incidence of adnexal masses(cystic/cystic)in the initially diagnosed BC patients and BC patients after systemic therapy were significantly higher than that in the normal population(9.5%,10.1% vs5.0%,p<0.05).The incidence of adnexal masses in patients during chemotherapy decreased sigificantly.The incidence of cervical cysts in patients with benign breast disease and BC patients(including initially diagnosed,during chemotherapy,and after systemic therapy)were 35.4%,32.2%,29.4%,35.1%,which compared with normal population(21.5%),increased significantly(p <0.05).But there was no significant difference in the incidence of cervical cysts between benign breast diseases and malignant breast diseases.3.In the population aged 60 years or more,the endometrial thickness of BC patients were significantly higher than the normal population,with statistical differences.There was no statistically significant difference among the three breast cancer patients groups.Conclusion:1.The incidence of breast nodules in patients with gynecological benign and malignant diseases were higher than that in normal people.2.Patients with benign breast disease and BC patients(including initially diagnosed,during chemotherapy,and after systemic therapy)had a higher probability of uterine mass(considering uterine fibroids or adenomas)than normal population.3.The incidence of adnexal masses(cystic/cystic)in the initially diagnosed BC patients and BC patients after systemic therapy were significantly higher than that in the normal population(9.5%,10.1% vs5.0%,p<0.05).The incidence of adnexal masses in patients during chemotherapy decreased sigificantly.4.The probability of cervical cysts in patients with benign breast diseases and BC patients were significantly higher than that of normal people.5.In the population aged 60 years or more,the endometrial thickness of BC patients was significantly higher than the normal population.6.We should pay more attention to the screening of breast nodules inpatients with gynecological benign and malignant diseases,and also need to pay attention to the screening and treatment of gynecological diseases for breast diseases patients. |
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