| Background: Gastric carcinoma is one of the most common malignant tumors in the world,and also one of the tumors with high mortality.China is also a high incidence area of gastric cancer,and the incidence rate has increased rapidly in recent years,which may be closely related to China's rapid economic development,heavy environmental pollution and dietary safety problems in recent years.Currently,surgical resection and postoperative adjuvant chemotherapy are still the main treatment methods for gastric cancer patients in China.Currently,relevant guidelines and expert consensus agree that adjuvant chemotherapy is beneficial for patients with gastric cancer after radical resection and can improve the 5-year survival rate.However,abnormal liver function caused by chemotherapy drugs can delay the cycle of chemotherapy and even stop chemotherapy,thus affecting the effect of postoperative treatment for gastric cancer and the quality of life,and even leading to liver failure and life-threatening.However,there is a trend of abuse of liver protection drugs in postoperative chemotherapy patients with gastric cancer,which greatly increases the economic burden of postoperative chemotherapy patients with gastric cancer.Therefore,in clinical work,early detection and early correction of liver function abnormalities in postoperative chemotherapy patients with gastric cancer should be carried out as far as possible,and liver protection drugs should be used reasonably to make postoperative chemotherapy standardized and smooth.Objective: The incidence,clinical features and related factors of abnormal liver function in patients with gastric cancer after chemotherapy were discussed.Methods: A retrospective analysis of the characteristics of liver dysfunction in post-operative chemotherapy of gastric cancer patients hospitalized in The First Affiliated Hospital of Henan University of Science and Technology from June 2015 to June 2018,using the chi-square test for single factor analysis of abnormal liver function and clinical features of contact,and then using multiariable logistic regression analysis model of postoperative chemotherapy for gastric carcinoma patients with abnormal liver function related factors.Results: There were 115 patients with abnormal liver function in 371 patients with gastric cancer after chemotherapy,the incidence rate was 31.00%.98 patients with grade 1 liver dysfunction 12 patients with grade 2 liver dysfunction 5 patients with grade 3 liver dysfunction.A total of 2210 cycles(average 5.96 cycles)of normal chemotherapy were performed.21 cases of liver injury were diagnosed according to the diagnosis of liver injury.The main type of liver injury was hepatocyte injury.Correlation factor analysis showed that long-term drinking,complicated with viral hepatitis B,and grade 2 or more digestive tract reaction during chemotherapy were the risk factors of abnormal liver function in patients with gastric cancer after operation(OR=2.662,5.559,1.841,all P < 0.05).Prophylactic use of hepatoprotective drugs is a protective factor(OR=0.442,P < 0.05).Conclusion: In this study,Long-term drinking,combined with viral hepatitis b and the occurrence of grade 2 or above gastrointestinal reactions during chemotherapy are risk factors for liver dysfunction in patients undergoing postoperative chemotherapy for gastric cancer.Prophylactic use of hepatoprotective drugs is a protective factor for liver dysfunction in patients undergoing postoperative chemotherapy for gastric cancer.It is suggested that postoperative chemotherapy for gastric cancer patients with the above risk factors should be adjusted in time to reduce the dose of chemotherapy drugs,and prophylactic hepatoprotective therapy should be given as soon as possible to reduce the occurrence of chemotherapeutic liver dysfunction.out. |
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