Curative Effects Of Postoperative Radiochemotherapy Compared With Chemotherapy Alone In The Treatment Of Advanced Gastric Cancer

Objective: Patients with advanced gastric cacer often easily relapse after surgery. Atpresent the postoperative chemotherapy or chemotherapy role is still controversial. Thepurpose of this study was to observe the short-term adverse effects and efficacy ofradiotherapy combined with synchronous chemotherapy using oxaliplatin andcapecitabine for advanced gastric cancer postoperation．Methods:70patients of advancedgastric cancer with total or subtotal gastrectomy and D2dissection were divided into twogroups,35patients received chemotherapy and radiotherapy(CT-RT group),35paeientsrectived chemotherapy(CT group), Radioation was given to a total dose of45Gy deliveredin25fractions by use of3D-CRT and chemotherapy with Capecitabine1650mg，4-6cycles of synchronous with Oxaliplatin130mg(in the first day)and (take orally in the day1to14)in21days. CT group using XELOX scheme (oxaliplatin and capecitabine), dosegroup with CT-RT group,4-6cycles. Results: The1-year,2-year,3-year survival rates inCT-RT group and CT group were85.7%、80.0%、62.9%and71.4%、54.3%、34.3%(P<0.05).The peritoneal recurrence rate in1-3years were much lower in CT-RT group（8.6%、14.2%、20%）than those of CT group（31.4%、40%、54.3%）(P<0.05).The adverseeffects of the CT-RT group were more serious than those in CT group,especially,Theincidence of the nausea was42.9%、17.1%,respectively(P<0.05),Howere,The incidence ofthe myelosuppression was34.3%、22.9%,respectively (P>0.05). The incidence of thereversible grade I～Ⅱ neurosensory toxicity Was20.0%、17.1%,respectively (P>0.05)．Conclusion: Radiation combined with synchronous chemotherapy with oxaliplatin andcapecitabine can increase the survival rate in patients with radical surgery for progressinggastric carcinoma and show good,efficacy,The major adverse effects were nausea and myelosuppression,the patients were tolerable．...