| Background:Lung cancer is one of the leading causes of cancer death throughout the world.The prognosis of the disease depends on many factors including the stage and type of cancer.Many studies have identified various microRNAs?miRNAs?that affect lung cancer's prognosis.In order to systemically analyze the available clinical data,we performed a meta-analysis to examine all evidence on the potential role of miRNAs as novel predictors of survival in lung cancer.Methods:We searched literature published in English before 01st February,2018 through PubMed to review all the associations between individual miRNA and groups of miRNAs with the prognosis of lung cancer.Data was extracted using standard forms and pooled odds of ratios?ORs?with 95%confidence intervals?CIs?were calculated.Results:Fifteen eligible studies were included in the meta-analysis.These represented1,753 lung cancer patients and 20 miRNAs.A Total of 8 miRNAs with down-regulation were associated with poorer overall survival?OS?(HR=0.59,95%CI 0.47-0.75,P<1×10-4),while10 miRNAs with up-regulations were associated with poorer OS(HR=1.76,95%CI 1.31-2.35,P<1×10-4).Additionally,low miRNA expression was associated with lymph node metastasis?LNM?(RR=0.53,95%CI 0.46-0.61,P<1×10-4).The expression of miRNAs was not associated with lung cancer stage?RR=1.07,95%CI 0.94-1.22,P=0.23?.Conclusion:Expression levels of different miRNAs were associated with OS and LNM of lung cancer patients.These miRNAs may be applied as potential prognostic markers in lung cancer. |
PDF Full Text Request