Analysis Of Coagulation Index In Early Premature Infants With Asphyxia,Placental Abruption And Premature Rupture Of Membranes

Neonatal hemorrhagic disease has become an important factor affecting the life and health of newborns.The prevalence of premature infants,especially early preterm infants,has increased year by year.With the continuous advancement of contemporary medicine,more and more newborns with small gestational age,low birth weight and even very low or extremely low birth weight have survived,but they have combined with hypoxemia,infection,etc.,combined with their own system development.Perfect,it is prone to coagulation dysfunction,causing or aggravating the occurrence of hemorrhagic diseases,and the mortality rate is high.The key is the early prevention and identification of coagulopathy.However,the current reference range of conventional coagulation indicators is often applied to preterm neonates with full-term or large gestational age.There is no uniform standard for coagulation indicators in preterm infants with small gestational age,which makes it difficult to judge whether the coagulation function of such children is abnormal.This study provides a clinical basis for the early prevention of this disease by analyzing the coagulation parameters of early preterm infants with different factors.Objective:To study the effects of asphyxia,placental abruption and premature rupture of membranes on coagulation indices in early preterm infants.Methods:1.A total of 150 early-preterm infants(25⁺⁵³3⁺⁶ weeks)born in Affiliated Hospital of Chengde Medical College from 2017.12-2018.11 were enrolled.The study subjects were divided into asphyxia group?39cases?,placental abruption group?21 cases?,and premature rupture ofmembranes group?44 cases?,with pregnancy-induced high-risk group?46cases?as the control group.Plasma coagulation function prothrombin time?PT?,activated partial thromboplastin time?APTT?,thrombin time?TT?,the level of fibrinogen?FIB?,fibrin degradation product?FDP?,D-Dimer?DD?,antithrombin III?AT-III?were detected within 6 h after birth,and compared.2.Analyzed the clinical data of 150 research objects,applied spss19.0software to process data.Enumeration data were expressed as percentages and rates,?² test was used for comparison between groups.Measured data were expressed as mean±standard deviation.One-way analysis of variance was used for comparison between groups.For statistically significant results,SNK-q test was used for pairwise comparison.Measurement data of non-normal distribution were described by median?interquartile range?.Using the Kruskal-Wallis H test and Nemenyi multiple comparison,p<0.05was considered statistically significant.Results:The APTT,PT and DD in the asphyxia group and placental abruption group were higher than those in the premature rupture of membranes and pregnancy-induced hypertension group?p<0.05?.The FIB was lower than the premature rupture of membranes and the pregnancy-induced hypertension group?p<0.05?There was no significant difference in the index between the asphyxia group and the placental abruption group,the premature rupture of membranes and the pregnancy-induced hypertension group?p>0.05?.Conclusion:Early preterm infants with placental abruption and asphyxia are more prone to coagulation abnormalities.Coagulation abnormalities can be found early by evaluating the level of APTT and PT,FIB,DD of high-risk neonates,timely intervention,aiming to avoid clotting mechanism is out of control,reduce the hemorrhagic diseases,improve the quality of life.