The Correlation Between TCM Syndromes And Objective Indexes Of HBeAg-negative Post-hepatitis B Cirrhosis

Objective:To observe the distribution of TCM syndromes in patients with HBeAg-negative post-hepatitis B cirrhosis,and to analyze the internal relationship between different TCM syndromes and objective laboratory indicators,Child-pugh classification,so as to provide objective theoretical basis for TCM syndrome differentiation and treatment of HBeAg-negative post-hepatitis B cirrhosis.Methods:This experiment is a retrospective analysis.According to the purpose of the experiment,136 cases of digestive and infectious department meeting the inclusion and exclusion criteria were collected from the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine from March 2015 to December 2018.The patients' names,gender,age,course of disease,TCM syndromes,main liver function indicators(AST,ALT,TBIL,DBIL,ALB,?-GGT,ALP,CHE),PT,AFP and Child-pugh classification were recorded in detail.establishing Excel database,using SPSS22.0 statistical software for statistical analysis,the results of measurement data are expressed as mean ±standard deviation,?2 test for counting data,rank sum test for ranking data,and one-way ANOVA or non-parametric test for comparison between groups,with statistical significance of P<0.05 and P<0.01.Results:1.The incidence of HBeAg post-hepatitis cirrhosis in males is higher than that in females.It is more common in middle-aged and elderly people.The incidence of HBeAg post-hepatitis cirrhosis in males is 46-55 years old,and in females is 56-55 years old.2.The distribution of TCM syndromes is dominated by damp-heat accumulation syndrome,liver-qi stagnation syndrome and water-wet internal resistance syndrome.3.In this study,39 cases(28.7%)were in compensation period and 97 cases(71.3%)were in decompensation period.There were significant differences in clinical stages of Western medicine among different TCM syndromes(P<0.01).4.The relationship between TCM syndromes and liver function indexes in 136 patients: At the level of ALT and AST,damp-heat accumulation syndrome was the highest.There was no significant difference in ALT among TCM syndromes(P > 0.05).There was significant difference in AST value between damp-heat accumulation syndrome and Liver-qi Stagnation Syndrome(P < 0.05).On the mean value of CHE,the syndrome of stagnation of Liver-qi > accumulation of damp-heat > internal obstruction of Water-dampness > deficiency of liver-kidney Yin > stagnation of blood stasis > deficiency of spleen-kidney yang,the syndrome of stagnation of Liver-qi has statistical significance compared with the other five syndromes(P < 0.05).On the mean value of ALB,there were significant differences between liver-qi stagnation syndrome,blood stasis syndrome,Water-dampness internal obstruction syndrome,damp-heat accumulation syndrome,liver-kidney Yin deficiency syndrome,spleen-kidney Yang deficiency syndrome and liver-qi stagnation syndrome compared with the other five syndromes(P < 0.05).At the level of TBIL and DBIL,there were significant differences between damp-heat accumulation syndrome,spleen-kidney Yang deficiency syndrome,liver-kidney Yin deficiency syndrome,blood stasis obstruction syndrome,Water-dampness internal obstruction syndrome,liver-qi stagnation syndrome and damp-heat accumulation syndrome(P < 0.05).At the level of TBA,there were significant differences between damp-heat accumulation syndrome,spleen-kidney Yang deficiency syndrome,water-damp internal obstruction syndrome,liver-kidney Yin deficiency syndrome,blood stasis obstruction syndrome and Liver-qi Stagnation syndrome,and between liver-qi stagnation syndrome and damp-heat accumulation syndrome and spleen-kidney Yang deficiency syndrome(P < 0.05).At the level of ALP,there were significant differences in dampness-heat accumulation syndrome,Water-dampness internal obstruction syndrome,spleen-kidney Yang deficiency syndrome,liver-kidney Yin deficiency syndrome,liver-qi stagnation syndrome,blood stasis obstruction syndrome,liver-qi stagnation syndrome,blood stasis obstruction syndrome and dampness-heat accumulation syndrome(P < 0.05).At the level of gamma-GGT,there was no significant difference among TCM syndromes(P > 0.05).5.The relationship between TCM syndromes and PT in 136 patients: On PT value,damp-heat accumulation syndrome was the longest,Liver-qi Depression Syndrome was the shortest,damp-heat accumulation syndrome,spleen-kidney Yang deficiency syndrome and Liver-qi Depression Syndrome were significantly different(P < 0.05).6.The relationship between TCM syndromes and AFP in 136 patients: The mean value of AFP in damp-heat accumulation syndrome was the highest,while that in Liver-qi Depression Syndrome was the lowest.There was no significant difference between the six TCM syndromes(P > 0.05).7.The comparison between TCM syndromes and child-pugh grading in 136 patients: child-pugh grading in 136 patients was highest in grade B(43.38%),followed by grade C(29.41%)and grade A(27.21%).A level mainly diseases with ease,damp and hot accumulate knot card in A,B,C level 3,level but with B,C,wet resistance are mainly distributed in class B,liver and kidney Yin deficiency syndrome,spleen and kidney Yang deficiency are mainly distributed in two grade B,C,blood stasis resistance network card in A,B,C level 3 distribution is uniform,between different TCM syndrome types Child-Pugh,grade difference was statistically significant(P < 0.05).Conclusion:The TCM syndrome types of HBeAg post-hepatitis B cirrhosis are intrinsically related to AST,TBA,TBIL,DBIL,ALB,ALP,CHE,PT and Child-pugh classification,which indicates that the objectification of TCM syndrome differentiation and treatment of HBeAg post-hepatitis B cirrhosis is feasible.