| ObjectiveAnalysis of HBeAg-negative chronic hepatitis B patients with different alanine aminotrans ferase levels, viral load, pathological grade, syndrome element distribution of age, the patient’s disease location, disease resistance syndrome element characteristics were analyzed and summarized, for Chinese medicine dialectical treatment of HBeAg-negative chronic hepatitis B provide an objective basis.MethodsCollected from January 2013 -December 2014 HBeAg negative First Affiliated Hospital of Anhui Medical University infection wards and outpatient clinics 124 patients with chronic hepatitis B, through four diagnostic clinical data collected standardization, the use of syndrome elements dialectical analysis HBeAg-negative chronic hepatitis B patients with different levels of alanine aminotransferase, viral load, pathological grade, permits the distribution of prime age for sick patients, the disease characteristics of the syndrome elements were analyzed and summarized.Results1. HBeAg-negative chronic hepatitis B patients, male 96 cases (77.5%), female 28 cases (22.5%); 30≤Y<40 age group the highest proportion, a total of 42 cases,33.8% of the total number of cases; 30-the largest proportion between the age of 60, there are 96 cases (77.3%), the number of cases at least 20 years of age for the four cases (3.2%). Age structure than the difference was not statistically significant (P> 0.05).2. HBeAg-negative chronic hepatitis B liver disease Slip known for the highest frequency of liver syndrome factors accounted for 83.0%, followed by the spleen, kidney, stomach, gall bladder; solid venereal Qi stagnation syndrome elements to the highest frequency factors accounted for 76.6%, followed by a wet, hot, blood stasis, phlegm; imaginary venereal syndrome elements qi, yin main deficiency syndrome elements accounted for 83.8% frequency, the frequency of qi deficiency syndrome factors accounted for 80.6%, followed by Yang, blood, Yang Kang, sperm loss. Syndrome elements integral comparison Slip on common elements integral distribution, liver integral highest, followed by the spleen, kidney, stomach, gallbladder; liver syndrome elements and spleen, kidney, stomach, gall bladder disease Slip factors was statistically significant (P<0.05), the rest of the syndrome elements no statistical significance; Empirical syndrome elements common to most points qi stagnation, followed by followed by hot, wet, blood stasis, phlegm; qi stagnation syndrome and other diseases of the empirical comparison hormone were statistically significant (P<0.05), wet and qi stagnation, blood stasis syndrome prime integrator was statistically significant (P<0.05); common sex horm one deficiency syndrome most points for the deficiency, followed in order for the deficiency, Yang, blood, Yang Kang; qi deficiency s yndrome and other diseases of the empirical factors were significant differences (P<0.05); There were significant differences (P<0.05) and Yin Qi, Yang points.3. Slip disease-related factors and biochemical indices of comparison:alanine aminotransferase and liver and spleen were significantly correlated (P<0.05); total bilirubin and stomach were significantly correlated (P<0.05); prothrombin time and spleen were significantly correlated (P<0.05); disease resistance syndrome elements and biochemical indicators of relevance comparison:alanine aminotransferase and with Qi, Yang showed a significant correlation (P<0.05); total bilirubin and wet, hot showed a significant correlation (P<0.05); alkaline phosphatase was positively correlated with qi stagnation, where the spleen was significantly associated (P<0.05); prothrombin time and Qi, Yang showed a significant correlation (P<0.05)4. different levels of ALT syndrome elements integral comparison:two elements are the highest points of liver disease location. The two prime integrator disease Slip analysis found ALT≥2 × ULN group stomach, gall bladder syndrome element scores than ALT <2 × ULN set high, to compare the two groups was statistically significant (P<0.05); two disease resistance syndrome elements integral analysis, ALT≥2 × ULN prime integral heat syndrome group compared with ALT <2 × ULN high group, the two groups were compared statistically significant (P<0.01).5.different viral load syndrome elements integral comparison:The two groups were analyzed integral syndrome elements found in both groups with high viral load group Spleen integral elements of high low viral load group, with statistical significance between the two (P<0.05); high viral load group, wet, high-heat syndrome prime lower viral load group, with statistical significance between the two (P<0.05); high viral load group Qi Deficiency Syndrome prime lower viral load group high statistical significance between the two (P<0.05).6. ages syndrome elements integral comparison:the two elements integral syndrome were analyzed and found high age group liver, kidney, blood stasis, yin, yang, essence deficiency syndrome elements integral lower age group is high, the two integral elements of each permit statistical comparison, the results were statistically significant (P<0.05).Conclusions1.HBeAg-negative chronic hepatitis B patients with 30-50 year old males.2. the main disease location HBeAg-negative chronic hepatitis B factor for the liver, followed by the spleen and kidney. Therefore, from the liver, spleen, kidney of governance is important.3. HBeAg-negative chronic hepatitis B disease of the major elements of qi stagnation, followed by Qi deficiency, so qi stagnation is the main symptom of the disease.4.HBeAg-negative chronic hepatitis B common TCM syndrome factors and biochemical indicators of the presence of a certain correlation:total biiirubin and stomach, dampness, heat-related; prolong prothrombin time may be related to the spleen, Qi, Yang related; alkaline elevated phosphatase and blood stasis.5. higher transaminase HBeAg-negative chronic hepatitis B patients stomach, gallbladder, wet, hot obvious empirical based.6. the higher the viral load in patients with HBeAg-negative chronic hepatitis B temper deficiency, wet, hot obvious signs of deficiency mixed mostly.7. older patients with HBeAg-negative chronic hepatitis B patients with kidney essence deficiency, blood stasis, yang, yin more obvious symptoms, clinical syndromes in liver and kidney deficiency based. |
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