Discussion The Possible Relationship Between Homemade Wine And Madelung Syndrome

Objective:Through the determination of methanol,ethanol,cyanide and other components in home-brewed wine,to discuss the possible relationship between this wine and the occurrence and development of Madelung syndrome.Method:(1)Collect 10 portions of self-brewed low-alcohol wine and low-alcohol bottled wine from the city of Baise and surrounding areas,and determine the components such as methanol,ethanol and cyanide,also determine the changes in their concentrations with the extension of storage time;(2)Divide the 70 patients with Madelung syndrome into two groups,the alcoholic group and the non-alcoholic group,according to their drinking situation.Detect and compare their blood biochemistry and complications,then analyze and discusse the correlation between the occurrence and development of Madelung syndrome and self-brewed wine.Results:(1)There was no difference in ethanol concentration between self-brewing and commercially wine(P=0.885),the alcohol degree was similar,the homogeneity was good,methanol,cyanide and other tests were comparable.(2)No cyanide has been detected in any wine made by oneself or sold in bottles,meeting the national standard.(3)Methanol in both self-brewing and commercially bottled wine is lower than the national standard;However,the methanol concentration in self-brewing was significantly higher than that in commercial bottled wine(P<0.001).With the extension of storage time,methanol concentration in self-brewing showed a downward trend.(4)Among 70 cases of the patients with Madelung syndrome,50 cases(71.43%)were perennial alcoholics,and all of them were male(100%).20cases(28.57%)drinked no or a small amount of alcohol,2 cases(10%)were men,18 cases(90%)were women.There was a statistically significant difference in the proportion of male and female in the alcoholic group and the non-alcoholic group(P < 0.001).(5)92%(46 cases)in the 50 cases of patients with Madelung syndrome,who drinking all the year round,were type I.85%(17cases)in 20 patients with no or small amounts of alcohol were type?.There was a statistically significant difference in the proportion of types between the alcoholic group and the non-alcoholic group(P < 0.001).(6)Comparing the liver function of the patients in the alcoholic group and the non-alcoholic group,52%(26 cases)of the 50 alcoholics had abnormal liver function,and only 15%(3 cases)of the 20 patients with no or small amount of alcohol had abnormal liver function,showing statistically significant difference(P =0.005).(7)Patients with Madelung syndrome may present hyperuricemia(34.29%),fatty liver(34.29%),hyperlipidemia(17.14%),hypertension(8.57%),elevated blood glucose(2.86%),bronchial asthma(1.43%)and other complications.Moreover,patients with Madelung syndrome who drink heavily all year round are more likely to be associated with hyperuricemia(P < 0.05,with statistically significant difference).However,alcoholism does not increase the incidence of hyperlipidemia,hypertension,hyperglycemia,bronchial asthma and other complications in patients with Madelung syndrome(P > 0.05,no statistical difference).Conclusion :(1)It is not believed that cyanide in wine is related to the occurrence and development of Madelung syndrome.(2)The long-term accumulation of methanol,ethanol and their metabolites in wine may be related to the occurrence and development of Madelung syndrome.(3)The ratio of male to female in Madelung syndrome was about 2.89:1.Most male patients had a history of alcoholism,while none of female patients had a history of alcoholism.(4)Perennial alcohol are more likely to cause type I Madelung syndrome,thoese drinking none or only a little alcohol are more likely to cause type?Madelung syndrome.(5)Patients with Madelung syndrome who drink heavily all the year round are more likely to be accompanied by liver damage and hyperuricemia.