Correlation Between Red Cell Distribution With Neutrophil-to-Lymphocyte Ratio And Severity Of Coronary Artery Disease And Prognosis Of It

Objective: Investigate the correlation between Red cell distribution with(RDW),Neutrophil lymphocyte ratio(NLR)and the severity and prognosis of coronary artery disease in patients with coronary heart disease.Methods: Retrospectively Collected 145 patients diagnosed as coronary heart disease in the second hospital of shanxi medical university from june 2017 to december 2017 as observation group,patients in the observation group were divided into three subgroups with different degrees of coronary artery lesions,which was evaluated by Gensini method.During the same period,50 patients with no obvious abnormality in coronary angiography were selected as the control group.we collected basic information,assay index,and prognosis information in both groups.Pearson analysis,T test,univariate anova and logistic regression were used to analyze the correlation between RDW,NLR and severity of coronary artery.Patients in observation group were also divided into four subgroups by medians of RDW and NLR,whose relationship with MACEs were tested by kaplan-meier and Log rank.Results: Differences in white blood cell count,neutrophil counts,red blood cell distribution width,neutrophil lymphocyte ratio,homocysteine,and brain natriuretic peptide between patients with coronary heart disease or not have statistical significance.The correlated between RDW,NLR and Gensini score were positive[(r=0.705,P<0.001);(r=0.64,P<0.001)].Logistic regression showed that fasting blood glucose,erythrocyte distribution width,neutrophil lymphocyte ratio and homocysteine were closely correlated with Gensini score(P<0.05).The difference in MACE between patients with high RDW and high NLR and those with low RDW and low NLR was statistically significant(P=0.001,P<0.001),which was tested by Kaplan-meier method and Log rank.Conclusion:RDW and NLR were significantly positively correlated with the degree of coronary artery lesions,RDW and NLR were independent predictors of MACE events in CHD patients.