Pulmonary Ventilation And Airway Reactivity In Asthmatic Patients With Large Body Weigh

Objective:The characteristics of pulmonary ventilation function and airway reactivity in adult asthma patients with large body mass index are discussed in this paper by analyzing and comparing the results of pulmonary function and airway stimulation tests in people with different body mass index,so as to improve the cognition of asthmatic patients with large body mass index in clinical practice.Methods:Clinical data of 620 patients who were diagnosed with asthma in their first visited to the department of respiratory and critical diseases of the First Hospital of Shanxi Medical University from March 2018 to June 2018 were collected.They were divided into three groups according to different BMI:normal group,and obese group.Based on genders,patients in each group were divided into male and female subgroups.Statistical methods were used to compare and analyze the results of pulmonary function and airway stimulation tests in different groups and different genders.Results:The incidences of small airway dysfunction in normal group,overweight group and obese group were 0.00%,0.72%and 56.10%,respectively.And in both overweight and obese groups the FEF_75%was lower than the normal group,while the PEF was higher,and the differences were statistically significant（all P<0.05）.In the stimulation test indexes,Rrs cont was larger than that in the normal group,while Grs cont was smaller,and the differences were statistically significant（all P<0.05）.In each group,FVC%pred,Rrs cont were greater in females than in males,Grs cont and SGrs were lower than in males（all P<0.05）.FEF_25%-75%less in females than in males in the overweight and obese groups（P<0.05）.BMI in males was positively correlated with Rrs cont,and negatively correlated with Grs cont.While BMI was positively correlated with PEF,Rrs cont,and negatively correlated with Grs cont,Dmin,SGrs,and PD₂₀-FEV₁ in females.conclusion:Asthma patients have small airway dysfunction,and obesity can increase the incidence of small airway lesions,but does not aggravate the degree of small airway dysfunction.Increased BMI had no significant effect on airway sensitivity,but it do increase the basal airway resistance.When the levels of obesity are similar,small airway dysfunction,airway sensitivity and airflow limitation were more significant in women.Obesity may increase airway resistance and airway reactivity in women with asthma.