| Objective:The incidence of malnutrition is high in patients with cervical cancer.To discuss the influence of nutritional intervention on patients of cervical cancer undergoing chemoradiotherapy.Methods:Sixty patients with cervical squamous cell carcinoma confirmed by pathology in the first hospital of shanxi medical university from October 2016 to October 2018 and treated with radiotherapy and chemotherapy in our department were selected.They are randomly divided into control group(30 cases)and the nutrition intervention group(30 cases),to observe the nutritional status of treatment in two groups of patients,the quality of life,incidence of adverse reactions,radiation and chemotherapy outage probability and complete cycle,hematology indexes change.Results:The results of the nutritional assessment of the patients with PG-SGA showed that: during the treatment,the scores of patients in the control group were 0-1 points,0 cases,2-3 points,4-8 points,9 cases,and 9 points of 9.In the intervention group,there were 0 patients with a score of 0-1,15 patients with a score of 2-3,12 patients with a score of 4-8,and 3 patients with a score of 9.The incidence of moderate and severe malnutrition in the control group and the intervention group was 90%(27/30)and 50%(15/30),respectively,with statistically significant differences(z=-4.308,P<0.05).Radiation dose of 40 Gy,intervention group in some functional areas such as physical function,role function,emotional function and overall health scores higher than the control group,in the field of some symptoms such as fatigue,nausea and vomiting,pain,insomnia,loss of appetite,diarrhoea score lower than that in control group,showed that this group of patients with functional status and quality of life,the better,the difference was statistically significant(P<0.05).The incidence of acute gastrointestinal reaction was 96.7%(29/30)and 83.3%(25/30),respectively,in the control group and the intervention group.The incidence of bone marrow suppression was 96.7%(29/30)and 76.7%(23/30),respectively.The incidence and degree of urinary tract infection were similar between the two groups,with no statistically significant difference(P>0.05).The interruption rate of radiotherapy in the control group and the intervention group was 26.7%(8/30)and 6.7%(2/30),respectively,and the interruption rate of chemotherapy was 56.0%(14/25)and 26.9%(7/26),respectively,with statistical differences(P<0.05),and the interruption rate in the control group was significantly higher than that in the control group.The mean cycles of chemotherapy completed in the intervention group were higher than those in the control group(4.38±1.10,3.44±1.58).After treatment,WBC,RBC,HB,PLT and ALB values in peripheral blood of the two groups all decreased to different degrees.The differences of RBC,HB,ALB and TP in peripheral blood between the two groups before and after treatment were statistically significant(P<0.05),and the decreased values in the intervention group were significantly lower than those in the control group.Conclusion:1.Cervical cancer patients have a high incidence of malnutrition,and chemoradiotherapy can increase the incidence of malnutrition and aggravate the degree of malnutrition;2.Nutritional intervention can improve the nutritional status of patients with cervical cancer radiotherapy and chemotherapy and improve their quality of life;3.Nutritional intervention during radiotherapy and chemotherapy for patients with cervical cancer can reduce the incidence of adverse reactions,interrupt rate of radiotherapy and chemotherapy,increase the number of cycles of chemotherapy,and thereby improve the clinical efficacy;4.Nutritional intervention during chemoradiotherapy for cervical cancer patients can reduce the hematological toxicity caused by chemoradiotherapy;... |
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