| ObjectivesBy comparing and analyzing the improvement of various observation indexes before and after treatment of damp-heat stagnation syndrome of acute gouty arthritis,this paper evaluates the efficacy and safety of Tuwei Chubi Decoction in treating damp-heat stagnation syndrome of acute gouty arthritis,and provides reliable basis for clinical application,alleviation of patients'pain and further experimental research.MethodsIn this study,66 cases met the inclusion criteria were collected and randomly divided into experimental group(33 cases)and control group(33 cases).The experimental group was treated with Tuwei Chubi Decoction(twice a day)and loxoprofen sodium tablets(60 mg PO tid),while the control group was treated with loxoprofen sodium tablets(60 mg PO tid).The observation time was 7 days.The changes of joint pain,joint swelling,joint tenderness,limited movement,fever,thirst,restlessness,short urine,laboratory indicators(uric acid,erythrocyte sedimentation rate,C-reactive protein)and the time required for the disappearance of pain symptoms were observed and recorded before and after treatment respectively.The therapeutic effects of TCM syndromes and ACR were compared before and after treatment.Evaluation of disease efficacy.Statistical software SPSS24.0 was used for data processing and statistical analysis to evaluate the clinical efficacy.Results1 Comparison of the baseline of the two groupsThere was no statistical difference between the two groups in gender,age,course of disease,TCM symptom score,pain VAS score and laboratory indicators(UA,ESR,CRP),P>0.05,so there was no statistical difference between the two groups.2 Comparison of overall efficacyThe total effective rate of the experimental group was 96.87%.Among them,9 cases achieved clinical control,16 cases showed marked effect,6 cases were effective and 1 case was ineffective.The total effective rate of the control group was 84.37%.There were 5 cases of clinical control.14 cases of marked effect.8 cases of effective and 5 cases of ineffective.Statistical software analysis showed that there was significant difference between the two groups(P<0.05).It shows that the curative effect of the experimental group is more remarkable and the total effective rate is higher than that of the control group.3.Comparison of therapeutic effects among two groupsThere was significant difference between the experimental group and the control group(P<0.05).Joint pain,joint swelling,joint tenderness.limited movement,fever,thirst,upset,short urine,laboratory indicators(uric acid,erythrocyte sedimentation rate,C-reactive protein)were improved.4.Inter-group comparison of efficacy(1)The difference of symptoms and signs before and after treatment was compared between the two groups.The results showed that there were significant differences between the two groups in improving joint pain,movement limitation,fever,thirst,restlessness and short urine yellowness(P<0.05).The effect of the experimental group was better than that of the control group in improving appeal;the two groups had better effects in joint swelling,joint tenderness,laboratory indicators(ESR.CRP).)There was no significant difference between the two groups(P>0.05).which could not prove that the effect of the experimental group was better than that of the control sroup in improving tenderness and swelling.(2)There was significant difference iin pain relief time between the two groups(P<0.05).Compared with the control group,the pain relief time of the experimental group was faster.C hinese stvle(3)The difference of laboratory indexes before and after treatment showed that there was no significant difference between the two groups in improving ESR and CRP(P>0.05);There was significant difference in improving serum uric acid(P<0.05),indicating that in reducing serum uric acid,the test sister had better effect than the control roup.but in reducing ESR and CRP,it was not proven yet.The experimental group was better than the control group.5.Safety analysisBefore and after the study,the blood routine,urine routine,liver and kidney function and electrocardiogram were normal.Two patients in the control group experienced abnormal gastric pain and liver function during the treatment,and recovered to normal after symptomatic treatment.ConclusionTuwei Chubi Decoction combined with loxoprofen sodium tablets and loxoprofen sodium tablets alone in the treatment of acute gouty arthritis with Damp-heat stagnation syndrome can improve joint pain,joint swelling,joint tenderness,limited movement,fever,thirst,upset,short urine yellow,laboratory indicators(uric acid,erythrocyte sedimentation,C-reactive protein),but in addition to joint tenderness and joint swelling and pain,the former is effective.Compared with the latter,the overall curative effect is better,the total effective rate is higher,the improvement of TCM syndromes is more prominent,and pain relief is faster.It can be seen that Tuwei Chubi Decoction combined with loxoprofen sodium tablets has good clinical efficacy and safety in the treatment of gout,rheumatism and heat stagnation syndrome,which is worthy of further clinical application.Chinese style... |
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