| Object iveThe purpose of this study was to explore the clinical efficacy of Jieqigui Wuwu decoction in the treatment of children with chronic asthma,and to analyze the advantages and disadvantages of this decoction in relieving childrenundefineds asthma compared with conventional western medicine.In order to give full play to the characteristics of traditional Chinese medicine in the treatment of chronic asthma,and to provide a new way of thinking for children with asthma.MethodsUsing cohort study method,90 chi l dre.n with Chronic duration of asthma in out-patient department of the first affiliated Hospital of Guangzhou University of traditional Chinese medicine,who were in accordance with Yingwei dissonance,were included.They were divided into three groups according to their parents undefined request.The children in the Chinese medicine group were given oral Chinese medicine:Astragalus mombranaceus,Guizhi,Radix Paeoniae Alba,Ziziphus jujuba and dried ginger.Pinellia pinelliae,Pori a cocos,Magnolia officinalis,almonds,grilled licorice,In the control group 1,the children were inhaled with budesonicle.Control group 2 was given montelukast orally.The course of treatment is 3 months.After the course of treatment,compare the three groups in the main therapeutic indicators,TCM syndrome integral changes.Finally,statistical analysis was used to evaluate.Results1.Total effective rateCompared with before treatment,the total ettect ive rate was 84.:38%in the traditional Chinese medicine group,89.66%in the budesonide group and 72.41%in the montelukast group at the end of treatment.(P<0.05).Compared with before treatment,the total effective rate was 81.25%in the traditional Chinese medicine group,79.31%in the budesonide group and 62.07%in the montelukast group at the end of the follow-up.(P<0.05).2.Total integral of TCM syndromeAfter treatment.,the total score of TCM syndrome in the three groups was significantly-lower than that before treatment(P<0.05).The total score of TCM syndrome in the Chinese medicine group was significantly lower than that in the other two groups(P<0.05),and the total score of TCM syndrome in the Chinese medicine group was significantly lower than that in the other two groups(P<0.05).At the end of follow-up,there was no significant difference between the total score of TCM syndrome and the end of treatment.(P>0.05)in the traditional Chinese medicine group as compared with the end of treatment(P>0.05).The total score of TCM syndrome in the traditional Chinese medicine group was significantly lower than that in the other two groups(P<0.05),and the total score of TCM syndrome in the Chinese medicine group was significantly lower than that in the other two groups(P<0.05).3.Different item integralAt the end of the treatment,the scores of each syndrome in the Chinese medicine group were significantly ciecreased compared wit.h those before treatment(P<0.05).In budesonide group and montelukast group,cough,asthma and total score were si gnificantly lower than t.hose before treatment(P<0.05).Compared with the other two groups,the scores of the Chinese herbs group were significantly lower than those of the other two groups(P<0.05)in the aspects of bad wind,self-sweating,cold limbs,thin stool and total integral.The score of cough and asthma in budesonide group was lower than that in traditional Chinese medicine group(P<0.05),and that in Chinese medicine group was lower than that in montelukast group(P<0.05).At the end of follow-up,the score of bad wind in TCM group was significantly higher than that at the end of treatment(P<0.05),but there was no significant change in the score of other syndromes(P>0.05).The scores of cough and asthma in the other two groups were significantly higher than those at the end of treatment(P<0.05),but there was no significant change in the scores of other syndromes(P>0.05).Compared with the other two groups,the scores of each syndrome and total score in the Chinese medicine group were significantly lower than those in the other two groups(P<0.05).The cough score and asthma score in budesonide group were lower than those in Mengruzast group(P<0.05).4.Number of asthma attacksAt the end of treatment,the number of asthma attacks in each group was lower than that before treatment(P<0.05).The frequency of asthma attack in budesonide group was less than that in traditional Chinese medicine group,while that in traditional Chinese medicine group was less than that inmontelukast group(P<0.05).At the end of follow-up,there was no signi ficant change in the number of asthma attacks in the Chinese medicine group as compared with the end of treatment(P>0.05),while the number of asthma attacks in the other two groups was significantly increased(P<0.05).The frequency of asthma attack in traditional Chinese medicine group was less than that in budesonide group(P<0.05),while that in budesonide group was less than that in montelukast group(P<0.05).5.Respiratory tract infectionsAt the end of the treatment,the number of respiratory tract infections in the traditional Chinese mcdicine group was significantly lower than that before treatment(P<0.05),but there was no significant difference between the other two groups(P>0.05).The number of respiratory tract infections in the traditional Chinese medicine group was significantly less than that in the other two groups(P<0.05),while that in the budesonide group and the montelukast group was about the same(P>0.05).At the end of follow-up,there was no signifieant change in the number of respiratory tract infections in each group compared with that at the end of treatment(P>0.05).The number of respiratory tract infections in the traditional Chinese medicine group was significantly less than that in the other two groups(P<0.05),while that in the budesonide group and themontelukast group was about the same(P>0.05).6.The PEF valuesAt the end of the treatment,the PEF:values in the three groups were significantly higher than those before treatment(P<0.05),compared with those in the pre-treatment group(P<0.05).The PEF of budesonide group was higher than that of traditional Chinese medicine group(P<0 05),and that of montelukast group was inigher than that of montelukast group(P<0 05).At the end of follow-up,there was no significant change in PEF in the Chinese medicine group compared with that at the end of the treatment(P>0.05),while the PEF in the other two groups was significantly decreased(P<0.05).Compared with the control group,the PEF values in the Chinese herbal medicine group were higher than those in t.he budesonide group,while the PEF values in the budesonide group were higher than those in the montelukast group(P<0.05).Conclusion1.TCM Syndrome and Respiratory tract infectionAt the end of the treatment,compared with the pre-treatment group,the TCM group could significantly improve the TCM syndrome and reduce the number of respiratory tract infections.Except for the improvement of cough and asthma,the curative ef fect of asthma was not as effective as that of budesonide group,but the other syndromes were improved.The efficacy of reducing the number of respiratory tract infections was better than that of the other two groups.The other two groups could not improve the symptoms and reduce the number of respiratory infections except cough and asthma.The curative effect of budesonide group was more obvious than t.hat of traditional Chinese medicine group in improving cough and asthma,and the curat.ive effect of traditional Chinese medicine group was more obvious than that of montelukast group.From the end of the tre.atment to the end of the follow-up,the Chinese medicine group,except for the syndrome of bad wind,other syndromes did not aggravate significantly,respiratory tract infection did not increase significantly.The other two groups had no obvious effect in improving the sympt.oms other than cough and wheezing and reducing the number of respiratory tract infections.2.Frequency of Asthma attacks and PEF MeasurementAt the end of treatment,compared with pre-treatment,budesonide group had the best curative effect on reducing the number of asthma attacks and increasing PEF,followed by traditional Chinese medicine group,and Montelukast group had the worst curative effect.From the end of treatment to the end of follow-up,there was no significant change in the number of asthma attacks in the traditional Chinese medicine group,while the other two groups were significantly increased.In terms of PEF,there was no significant change in the traditional Chinese medicine group,while the ot.her two groups decreased significantly.3.SummaryAt the end of the treatment,budesonide group had a significant advantage over the other two groups in terms of total cffective rate,improvement of cough,asthma symptoms,reduction of asthma attacks and improvement of PEF(i.e.,improvement of airway stenosis),while Chinese medicine group had significant advantages over other two groups in improving TCM syndrome score.Reducing the number of respiratory infections is more advantageous than the other two groups.At the end of the follow-up,the total effective rate and other therapeutic indexes in the Chinese medlicine group were better than those in the other two groups.Therefore,the curative effect of the Chinese medicine group in controlling asthma may be more comprehensive,lasting longer,more stable,and the symptoms are not easy to repeat.Therefore,on the basis of syndrome differentiation,oral Chinese medicine and nebulized inhalation of budesonide have advantages,and oral Chinese medicine is better than oral montelukast sodium. |
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