| Objective1.Clinical study on chronic gastritis patients with anxiety and depression.In this study,the clinical survey of chronic gastritis,patients reported outcomes instrument for Chinese gastroenterology diseases scale(ChGEDPRO)and Hospital Anxiety and Depression Scale(HADS)were performed in all subjects.?To compare the anxiety,depression and quality of life scores of chronic gastritis patients(trial group)with those of healthy participants(control group).?To evaluate anxiety and depression and syndrome scores,quality of life and syndrome score in chronic gastritis patients.This study seeked to improve knowledge of this condition and curative effects.2.Observing the efficacy of the liver-soothing stomach harmonising formula combined with catgut embedding in patients with chronic gastritis in term of disharmonious relationship between liver and stomach.Based on the control study of the effectiveness and safety of the liver-soothing stomach harmonising formula combined with catgut embedding on chronic gastritis,the tutor proposed a new curative method for chronic gastritis.This study established the clinical efficacy of the liver-soothing stomach harmonising formula combined with catgut embedding in the treatment of chronic gastritis with anxiety depression of liver stomach type,and this curative method shows improvements on the quality of survival,and proposed an initial discussion on the treatment mechanism of the liver-soothing stomach harmonising formula combined with catgut embedding.Methods1.Evaluation of chronic gastritis patients with anxiety and depressionA cross-sectional study involved 300 cases including chronic gastritis patients and healthy participants from the department of gastroenterology of the first affiliated hospital of Guang Zhou University of Chinese Medicine from December 2017 to February 2019.The scores of anxiety,depression and quality of life were evaluated in a sample size of 300 cases devided into 2 groups:200 chronic gastritis patients and 100 healthy cases respectively.Chronic gastritis clinical questionnaire and Chinese spleen and stomach disease PRO scale(ChGEDPRO)and Hospital Anxiety and Depression Scale(HADS)were used.SPSS 22.0 was used for statistical analysis.The average scores of anxiety,depression and quality of life of chronic gastritis patients were statistically analyzed,and the average scores of anxiety,depression and quality of life of chronic gastritis patients were compared with those of anxiety,depression and quality of life of healthy people.2.Observation of the clinical efficacy of the liver-soothing stomach harmonising method(kai yu he wei method)combined with catgut embedding in patients with chronic gastritis in term of disharmonious relationship between liver and stomach.Cohort study method were used to randomly select 80 chronic gastritis patients marked by the syndrome of disharmony between liver and stomach that met the inclusion criteria from the outpatient department of the department of gastroenterology of The first affiliated hospital of Guang Zhou University of Chinese Medicine from December 2017 to February 2019.The cohort group was divided into two groups:the treatment group(40 cases)and the control group(40 cases),which were all treated for 4 weeks.Before treatment and 4 weeks after treatment,the clinical characteristics questionnaire of chronic gastritis,PRO scale of spleen and stomach,HADS scale were filled in,and the TCM syndrome scale was evaluated once each.Through statistical analysis,this paper evaluated the curative effect of the liver-soothing stomach harmonising method combined with catgut embedding therapy on symptoms,anxiety and depression,and quality of life of chronic gastritis patients,and explored the mechanism of this combination.Results1.Clinical study on chronic gastritis patients with anxiety and depression.(1)Age and sex:there were 118 male and 82 female CG patients,and 47 male and 53 female healthy participants.In the CG group,the youngest and the oldest age were 21 years old and 63 years old respectively,the average age was 40.96±10.30 years old;the average age of men and women were 38.97±10.02 years old and 43.38±9.80 years old respectively.In the healthy group,the youngest and oldest ages were 21 years old and 65 years old respectively,the average age was 38.80±11.25 years old;the average age of men and women were 37.35±10.20 years old and 40.50±12.28 years old respectively.There was no significant difference in the mean age between two groups(P>0.05).(2)There were 103 young patients aged 21-40 years,87 middle-aged patients aged 41-60 years and 10 patients aged over 60 years.The morbidity of young males was higher than that of young females,with statistical significance among different age groups(P<0.05).(3)Among 200 CG patients,there were 15 primary school graduation cases,58 middle school graduation cases,55 secondary and high school graduation cases,59 junior college and undergraduate cases,and 13 graduate cases.Among 100 healthy participants,there were 9 primary school graduation cases,20 middle school graduation cases,22 secondary and high primary school graduation cases,36 junior college and undergraduate,and 13 graduate cases.In the two groups,the proportions of those with a graduate degree or above were relatively low.(4)There was a statistically significant difference in anxiety and depression score between CG patients and healthy people(P<0.05),indicating that CG patients were significantly different from healthy participants in anxiety and depression.(5)Comparing the quality of life scale between CG group with healthy group,the scores in the four fields between two groups were statistically significant(P<0.05),indicating that there were significant differences between CG patients and healthy participants.(6)In this study,the labor distribution of 200 CG patients was 70 cases of manual labor and 130 cases of mental labor.Among the 100 healthy people,there were 44 cases of mental labor and 56 cases of mental labor.(7)Among GC patients,superficial gastritis(40%),bile reflux gastritis(30.0%),flat erosive gastritis(30.0%),It is obvious to indicate that the chronic gastritis with the highest proportion of gastroscopy results was superficial gastritis?(8)Syndromes:liver-stomach discord(78.5%),Non liver-stomach discord(21.5%),the syndrome with the highest proportion was liver-stomach discord.(9)The score of the anxiety and depression subscale was asymptomatic in 0-7,suspicious in 8-10,suspicious in 11-21,positive in 8,including suspicious and symptomatic.Among the 200 patients investigated,16.0%had no anxiety,62.0%had anxiety,22.0%had anxiety disorder,55.0%had no depression,30.0%had depression and 15.0%had depression disorder.2.Observation the efficacy of the liver-soothing stomach harmonising method combined with catgut embedding in chronic gastritis patients in term of disharmonious relationship between liver and stomach.(1)This study included 80 chronic gastritis patients with anxiety and depression.The patients were divided into two groups:treatment group(40 cases)and control group(40 cases).There was no significant difference between the two groups in terms of gender,age,stages of disease,symptom score before the first treatment,HADS score and quality of life score(P>0.05).(2)After 4-week treatment,in total CG patients,8 patients in the treatment group recovered,accounting for 20.0%;10 cases were markedly effective,accounting for 25.0%;20 cases were effective,accounting for 50.0%;2 cases were ineffective,accounting for 5.0%;and the total effective rate was 95.0%.In the control group,5 cases were cured,accounting for 12.5%;6 cases were markedly effective,accounting for 15.0%;24 cases were effective,accounting for 60.0%of the total;5 cases were ineffective,accounting for 12.5%of the total;and the total effective rate was 87.9%.There were significant differences in the scores of clinical symptoms before and after treatment(P<0.05).The difference of clinical symptom scores between the two groups before and after treatment was statistically significant(P<0.05).There were significant differences in the scores of clinical symptoms between the two groups after treatment(P<0.05).(3)The scores of anxiety and depression in each group were tested by t test before and after treatment,and the difference was significant(P<0.05).The difference of clinical anxiety and depression scores between the two groups before and after treatment was tested by t test,and the difference of anxiety state scores was statistically significant(P<0.05).There was no significant difference in depression score(P>O.05).There were significant differences in anxiety and depression scores between the two groups after treatment(P<0.05).(4)The scores of quality of life of each group before and after treatment were compared.T test showed that there were significant differences in the scores of four areas(P<0.05).There was no significant difference between the two groups before and after treatment(P>0.05).There were also three areas including independent area,psychological area and social environment area.There was significant difference between the two groups before and after treatment(P<0.05).There was significant difference in the quality of life score between the two groups after treatment(P<0.05).Conclusion1.Clinical study on chronic gastritis patients with anxiety and depression.(1)The ratio of anxiety is higher than that of depression in chronic gastritis patients,and the syndrome of disharmony between liver and stomach is the most common TCM syndrome in CG patients with anxiety and depression.(2)Comparison of anxiety and depression between 2 groups.Healthy people are significantly better than CG patients.(3)According to the comparison of physiological,independent,psychological and environmental aspects,these features of healthy group are evidently better than those of CG group.2.Observation of the efficacy of the liver-soothing stomach harmonising formula combined with catgut embedding in chronic gastritis patients in term of disharmonious relationship between liver and stomach.(1)The treatment effect of the liver-soothing stomach harmonising formula combined with catgut embedding in CG patients in accordance to the disharmony of liver and stomach is definite,which can effectively improve the symptoms of chronic gastritis patients,and the curative effect of improving anxiety and depression status and quality of life of patients is obviously better than those of using liver-soothing stomach harmonising formula alone.(2)The combination of the liver-soothing stomach harmonising formula combined with catgut embedding therapy contributes an effective compliance,which is safe and worthy to popularized in clinical treatment. |
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