Clinical Observation Of Primary Hypothyroidism With Wenshen Jianpi Huoxue Therapy

ObjectivesTo observe the effectiveness of Wenshen Jianpi Huoxue method combined with levothyroxine sodium tablets(L-T4)on patients with prima-ry hypothyroidism.To explore its possible mechanism and to promote app-lication.Methods66 patients were equally divided into two portions,the therapy group and the control ones,according to the random number table.The therapy group was given L-T4 together with Chinese medicine,while the other was L-T4 only,both for 8 weeks.By calculating the symptom score and SF-36 scale score,comparing the thyroid function,blood lipid and L-T4 dosage to assess the effectiveness of the two methods.Results1.The two methods both make significant differences in symptom scores(P<0.001),whi le it was more obvious in the therapy ones(P<0.01).It showed that Chinese medicine combine L-T4 can effectively ease the clinical symptoms of patients with hypothyroidism.2.FT3 and FT4 of these patients were significantly increased than before(P<0.01),at the same time hTSH were largely decreased(P<0.05).Comparaing to the control group,the variation of FT3?FT4 and hTSH were more obvious in the treated group(P<0.01)It showed that the combination methods could more effectively increase FT3 and FT4,lower the level of hTSH.3.The total curative effect were more than 80%for two groups,the combination therapy could ease the clinical symptoms,and refine the thyroid function.The efficiency of the therapy group was 93.94%,which was higher than that of the other one(81.82%).It was no doubt that the combination method had an advantage over the L-T4 alone.4.After treating,TC,TG and LDL-C were drastically decreased(P<0.01),HDL-C was increased(P<0.01).There were significant differences in TC,TG,LDL-C,and HDL-C between the two groups(P<0.05).It indicated that combination method and only L-T4 could reduce TC,TG,LDL-C and escalate HDL-C,and the former one done better.TPOAb decreased significantly(P<0.01),there was no significant difference in TPOAb(P>0.05),which may due to the short research study cycle.5.The two methods could escalate SF-36 scale(P<0.01),and the differences of the two groups were clear(P<0.01).It showed that the two treatments could improve the quality of life of patients,but the former was better.Which is especially effective in improving Physical functioning,relieving Bodily Pain,Role-emotional and Mental Health(P<0.05).6.The doses of L-T4 between the two groups also made differences(P<0.05).At the beginning of the study,there was no significant difference between the two groups(P>0.05).There was a significant difference between the control group and the control group(P<0.01),it showed that Chinese medicine could reduce the dose of L-T4.7.For all patients the blood routine,liver and kidney function were in the normal range.SummaryThe two methods were safe for primary hypothyroidism patients,which can better the clinic symptoms,thyroid function,blood lipids and quality of life.The combination method had a certain advantage over L-T4.