TCM Syndrome Analysis Of Cerebral Infarction With Patent Foramen Ovale

ObjectiveTo study the TCM syndromes,analyze the age and gender,study the risk factors and pathogenesis of cerebral infarction with patent foramen ovale(PFO),and analyze the relationship between risk factors and the its TCM syndromes,in order to provide clinical ideas for dialectical diagnosis of TCM of it.MethodsUsing a retrospective study method,108 patients of cerebral infarction with PFO from the Department of Neurology of Shenzhen Second People' s Hospital,during the period from May 2017 to May 2018,were taken to form an observation group.108 patients were randomly selected from patients with cerebral infarction without PFO to form a control group.See Appendix 1 for the specific method.At the same time,the general information of the patients is collected,and the current medical history,past history,personal history and biochemical indicators are collected.The research items required for this study were extracted,including age,gender,smoking,drinking,migraine,whether there were venous thrombosis of lower extremities,hypertension,anti-cardiolipin antibody positive or not,ejection fraction,end-diastolic diameter,end-systolic diameter,etc.Under the guidance of 2 chief physicians,all patients were analyzed and recorded according to their symptoms,tongue and pulse,etc.,and the and statistical software was used for statistical analysis to obtain results.Results1.The age of the observation group was smaller than that of the control group.There was significant difference between the two groups(P<0.05).There were 67(663.9%)males and39(36.1%)females in the observation group,71(65.7%)males and 31 females(34.3%)in the control group.There was no significant difference between the two groups(P>0.05).2.There was a significant difference in ejection fraction,end-diastolic diameter,and end-systolic diameter between the two groups.3.The observation group RoPE scores was lower than the control group,and there was a significant difference between them(P<0.05).4.Among the risk factors of two groups,the observation group had more deep venous thrombosis(DVT),migraine,and anticardiolipin antibody(ACA)positive cases,but there was no significant difference in the risk factors of smoking,alcohol consumption and hypertension between two groups.(P>0.05).5.In the TCM syndrome analysis of the two groups of these patients,all patients were classified into qi deficiency and blood stasis,wind-yang nuisance type,liver and kidney deficiency type,and wind and phlegm bloke channel.There were 38 patients with qi deficiency and blood stasis in the observation group,accounting for 35.2%;22 patients with wind-yang nuisance type,accounting for 20.3%;28 patients with wind and phlegm bloke channel,accounting for 26.0%;and 20 patients with liver-kidney deficiency,accounting for 18.5%.In the control group,there were 17 patients with qi deficiency and blood stasis,accounting for 15.7%;24 patients with wind-yang nuisance,accounting for 22.2%;25 patients with liver-kidney deficiency type,accounting for 23.2%;42 patients with wind and phlegm bloke channel type,accounting for 38.9%.The patients in the observation group were mainly qi deficiency and blood stasis.The control group was mainly wind and phlegm bloke channel.(P<0.05)6.In the relationship between the TCM syndrome types and risk factors in the observation group,the number of migraine patients with wind and phlegm bloke channel type was significantly different from the number of patients with non-wind and phlegm bloke channel type.(P<0.05)Conclusion1.Patients with PFO and cerebral infarction was younger than that of patients with cerebral infarction.There was no significant difference in gender between the two types of patients.2.The overall cardiac function of patients with PFO and cerebral infarction was worse than that of patients with cerebral infarction.3.Patients with PFO and cerebral infarction had more migraine,DVT and anticardiolipin antibodies than non-PFO patients with cerebral infarction.They may be risk factors for PFO patients with ischemic stroke.4.The patients of cerebral infarction with PFO are related to abnormal embolus.5.The distribution of patients of cerebral infarction with PFO is qi deficiency and blood stasis type>wind and phlegm bloke channel type>wind-yang nuisance type>liver-kidney deficiency type.The distribution of patients of cerebral infarction without PFO is that wind and phlegm bloke channel type>liver-kidney deficiency type>wind-yang nuisance type>qi deficiency and blood stasis type.6.More patients who are wind and phlegm bloke channel type have migraine than other types of patients in cerebral infarction with PFO patients,and they have no significant association with other risk factors such as Deep venous thrombosis,migraine,anticardiolipin antibody.There is no significant association between the rest three types and these four risk factors.