Clinical Study Of Dangguiniantong Decoction In Treating Diabetic Peripheral Neuropathy

ObjectiveDue to the unique climatic and geographical environment in lingnan area and the influence of local diet and living habits,spleen deficiency and damp-heat constitution of lingnan people are caused,and damp-heat blocking type DPN is relatively common in lingnan area.This research is to obverse the changes before and after the therapy of Dangguiniantong decoction combined with Mecobalamin Tablets in damp-heatblocking type of Diabetic Peripheral Neuropathy,which includes the clinical curative effect,as well as the glucose-lipid metabolism?plasma neuregulin 4(Nrg4)?hypoxia-inducible factor(HIF-1?)?ankle brachial pressure index(ABI)?current perception threshold(CPT).The aim is to provide a reference for better individual treatment in DPN.MethodsBythe method of clinical observation,60 eligible patients with DPN were divided into control group and treatment group in accordance with the principle of randomized.While patients in both groups received conventional hypoglycemic treatment,the control group was treated with Mecobalamin Tablets,and the treatment group was treated withDangguiniantong decoction and Mecobalamin Tablets for 6 weeks.The changes of clinical symptom score,blood glucose,blood lipid,Nrg4,HIF-1?,ABI and CPT in the two groups were observed and recorded for statistical analysis.ResultsClinical symptoms:Before the treatment,the total scores of syndromes in both groups fell into no significant difference(P>0.05).After treatment,the total scores of syndromes in both groups was lower than that before treatment,and the difference was significant(P<0.05).After treatment,the total score of syndromes in the treatment group was significantly decreased compared with the control group(P<0.05).The difference of the total syndrome score before and after treatment was significantly higher than that in the control group(P<0.05).Glucose metabolism:Before the treatment,fasting blood-glucose(FPG)and 2 hour postprandial blood glucose(2hPG)of the two groups fell into no significant difference(P>0.05).After treatment,FPG and 2hPG in both groups were lower than before treatment,and the differences were significant(P<0.05).After treatment,the FPG and 2hPG in the treatment group were significantly decreased compared with the control group(P<0.05).The differences in FPG and 2hPG before and after treatment were significantly higher compared with the control group(P<0.05).Lipid metabolism:Before the treatment,4 blood lipids of the two groups fell into no significant difference(P>0.05).After the treatment,the triglyceride(TG),total cholesterol(TC)and low density lipoprotein cholesterol(LDL-c)of the treatment group were lower than that before and the differences were significant(P<0.05).Compared with that before the treatment,the differences of the high-density lipoprotein cholesterol(HDL-c)of the treatment group showed no significant significance(P>0.05).After treatment,the blood lipids of the control group fell into no significant difference(P>0.05).After treatment,the TG,TC in the treatment group were significantly decreased compared with the control group(P<0.05),and the differences in TG,TC before andafter treatment were significantly increased compared with the control group(P<0.05).The HIF-1?:Before the treatment,the HIF-1? of the two groups fell into no significant difference(P>0.05).After treatment,HIF-1? in the treatment group was lower than that before treatment,and the difference was significant(P<0.05),while HIF-1? in the control group was not significant(P<0.05).After treatment,HIF-1? significantly decreased in the treatment group compared with the control group(P<0.05),and the difference in HIF-1? before and after treatment was significantly increased compared with the control group(P<0.05).The Nrg4:Before the treatment,the Nrg4 of the two groups fell into no significant difference(P>0.05).After treatment,the Nrg4 of both groups fell into no significant difference(P>0.05).After treatment,compared with that of the control group,the Nrg4 and the difference of Nrg4 before and after treatment fell into no significant significance(P>0.05).The ABI:Before the treatment,the ABI of the two groups fell into no significant difference(P>0.05).After treatment,the ABI increased in the treatment group compared with that before treatment,and the difference was significant(P<0.05),while ABI in the control group was not significant(P<0.05).After treatment,the ABI was significantly increased in the treatment group compared with the control group(P<0.05).The difference of the ABI before and after treatment was significantly higher than that in the control group(P<0.05).The CPT:Before the treatment,the CPT of the two groups fell into no significant difference(P>0.05).After treatment,the CPT in both groups was lower than that before treatment,and the difference was significant(P<0.05).After treatment,compared with the control group,the CPT in the treatment group was significantly lower(P<0.05).The difference of the CPT before and after treatment was significantly higher than that in the control group(P<0.05).ConclusionDangguiniantong decoction combined with mecobalamine tablets in the treatment of damp-heat blocking type DPN is superior to mecobalamine tablets alone in improving the clinical symptoms,blood glucose and nerve injury of patients,and its mechanism may be related to the regulation of lipid metabolism,the improvement of oxidative stress,and the improvement of lower extremity vascular lesions.