| ObjectiveTo observe the clinical effect of Wenyang Tongbi method on function of patients with gout intermittent,compare the effection of the treatment group and the control group in TCM symptoms,blood uric acid level,quality of life score and related inflammation indicators,To confirm the role of and the effect on the treatment of Wenyang Tongbi method,and provide a new idea and treatment way to the patients with gout intermittent.MethodsFrom January 2018 to January 2019,the Department of Endocrinology and Inpatient Department of the Second Hospital of Guangdong Province and the Clifford Hospital of Guangdong Province were collected.140 patients with intermittent gynecological and genital gout-type gout were randomly selected and sampled by random number sampling.Randomized as control group and treatment group,each group with 35 patients.Both groups were treated with low-grade diet and have a healthy lifestyle.The control group was given benzbromarone 50mg once a day,and the Jiawei Guizhi Shaoyao Zhimu Decoction Granules are dissolved in 200ml of warm water in the treatment group.Both groups were treated for 12 weeks.All patients underwent UA(blood uric acid),ESR(erythrocyte sedimentation),CRP(C-reactive protein),liver function(ALT,AST),renal function(SCr,BUN),and blood lipids(TC,TG,HDL,LDL)before and after treatment.),quality of life score(SF-36 form)and TCM syndrome symptom score.Compare the statistical of the experimental group and the control group before and after treatment,and the statistical analysis was performed according to the comparison resul ts by using the SPSS22.0 statistical software.Results1.TCM symptom aspects:The rate of the effective of the treatment group was 93.1%,which was significantly better than the control group(53.3%)(P<0.01).2.Clinical indicators:①The control group was superior reducing in UA(P<0.01)Compared with the control group;Both of the groups was superior reducing in UA(P<0.01)after treatment,and the treatment group was more effective in reducing uric acid.②The control group was superior reducing in the ESR and CRP levels(P<0.01)Compared with the control group;The treatment group was significantly lower the ESR and CRP levels Better than the control group(P<0.01)after treatment.③The control group was superior reducing in the TC,TG and LD levels(P<0.01),and there was no significant difference in the reduction of HDL(P>0.05)Compared with the control group;The treatment group was significantly lower the TC,TG and LD levels Better than the control group(P<0.01)after treatment.④In terms of safety,there was no significant difference in ALT,AST,BUN and SCr compared with the control group(P>0.05).There was no significant difference in the reatment group and the control group in the level of ALT,AST,BUN and SCr(P>0.05).3.SF-36 score sheetThe control group was superior improve the level of the(energy VT,social function SF,emotional function RE,mental health MH,physiological function PF,physiological function RP,somatic pain BP,general health status GH,health change HT The score was superior to the control group(P<0.01)Compared with the control group.The treatment group was significantly improve the level of PF,RP,BP,GH,SF,RE,HT,VT and MH Better than the control group(P<0.01)after treatment.The treatment group was significantly improve the level of SF and VT scores(P<0.01),and has difference in PF,RP,BP,GH,RE,HT,MH after treatment(P>0.05).Conclus ionThe application of Wenyang Tongbi method not only can effectively reducethe UA level and inflammation indexes,but also can improve the TCM syndrome score an the quality of life of the patients.And the Wenyang Tongbi method can improve blood l ipid profile,lower blood lipid(TC,TG,LDL)levels and regulat the lipid metabolism.Wenyang TongTongbi method is worth to promote because it is safe and effective in the treatment of gout intermittent period. |
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