| Objective To analyze the epidemiological and clinical characteristics of cytomegalovirus infection in children,and to observe the efficacy and safety of ganciclovir in the treatment of cytomegalovirus.Method From January 2014 to December 2016,data of 5,442 children tested by elisa(TORCH Test case)in the pediatric outpatient department and inpatient department of the first affiliated hospital of bengbu medical college were selected.Gender and age differences of children with CMV IgG positive were analyzed,At the same time,blood and/or urine cmv-dna copy number were further examined in children with CMV IgM positive,the clinical manifestations,laboratory examination results,imaging results,treatment process,disease outcome and other data of positive children were analyzed retrospectively.Results(1)Among the 5442 patients,4040 were CMV-IgG positive,with a positive rate of 74.24%.Among them,3357 cases were boys and 2478 cases were CMV-IgG positive,with a positive rate of 73.82%.There were 2085 girls and 1562 CMV IgG positive cases,with a positive rate of 74.92%.There was no significant difference in the positive rate of CMV-IgG between boys and girls(P>0.05).The number of CMV-IgG positive cases was the most in children aged 1-3 months(24.6%),and gradually decreased after 1-3 months.At the same time,a total of 188 cases of serum IgM were tested positive,with a total positive rate of 3.31%.The number of CMV-IgM positive cases was up to 5.7% in children aged 3-6 months,followed by 3.5% in children at the age of 6 months to 1 years,and the positive rate gradually decreased with the increase of the age of months.(2)The damage of CMV infection on target organs of the host in children was related to the age of the children,among which liver function damage,pneumonia,hyperbilirubinemia,myelodysplasia,and the incidence of central nervous system symptoms were statistically significant(all P<0.05).However,there was no statistically significant difference in the incidence of myocardial damage,renal damage,diarrhea,and combined malformation in children(P>0.05).Malformation was morecommon in children under 1 year old,but no malformation was found after 1 year old.(3)Summarizes for the clinical manifestations of congenital heart disease,hydrocephalus,hernia of children were regularly temporarily give up treatment,clinical symptoms of bronchial pneumonia,liver function damage,myelodysplastic myocardial damage,high blood bilirubin,most prognosis is good,5 patients clinical manifestation for CMV encephalitis children,there are 4 cases were cured,1 case of families with children is not actively be discharged automatically.After treatment,33 cases were cured,accounting for 46.5%,29 cases were improved,accounting for 40.8%,and 9cases were not cured(4 cases were automatically discharged),accounting for 12.7%,with a total effective rate of 87.3%.Conclusions(1)The total positive rate of CMV-IgG serum in children aged 0-12 years in northern anhui was 74%,and the CMV infection was mainly latent infection in all ages(excluding infants less than 6 months old),children’s active infection mainly occurred within 1 year old,and the active infection rate in infants aged 3-6 months was the highest in all ages.(2)CMV infection in children is not related to gender,and damage to the target organs of the host is closely related to the age of the children,which can cause multi-organ and multi-system damage.The clinical characteristics are diverse,and multiple organs can be involved.(3)Ganciclovir is the first choice for treatment of CMV infection in children,the curative effect is remarkable,the side effect is small,it is worthy of clinical application. |
