| Objective:To evaluate the effect of raised maternal pre-pregnancy body mass index(BMI)on cognitive and metabolic profile of singletons following in-vitro fertilization(IVF)with or without intracytoplasmic sperm injection(ICSI).Methods:This is a study based on a cohort of 1904 IVF/ICSI singletons aged 3-6 years in china.Age-and sex-specific BMI z-scores by Chinese standard were xxsed to assess growth of children.Chinese Version of the Wechsler Intelligence Scale for Children(C-WISC)was performed to evaluate verbal intelligence quotient(VIQ),performance intelligence quotient(PIQ),and full intelligence(FIQ).Adjusted linear regression and logistic regression were used to controlquotient for confounding factors to evaluate relationship of maternal pre-pregnancy BMI and cognitive/metabolic profile offspring conceived through IVF/ICSI.Results:After adjusting for confounders,the obese women were more likely to have obese children(20.0%vs 5.1%,P=0.01)than normal BMI women,and overweight women had increased risks of having overweight children(13.6%vs 8.2%,P=0.02)or obese children(10.1%vs 5.1%,P=0.01).When not adjusting for parental educational level,offspring of the overweight women scored lower in VIQ,PIQ and FIQ than the normal weight women,while offspring of the obese women lower in both PIQ and FIQ.However,after adjusting for parental educational level,this result was not consistently observed in four groups.But after adjusting for confounders,offspring of obese women still showed increased prevalence of intellectual disability(IQ<80)in VIQ(16.9%vs 8.5%,P=0.03)and FIQ(10.8%vs 3.9%,P=0.03)compared with normal weight women.Conclusion:This study suggests that matermal pre-pregnancy obesity is associated with increased risks for obesity,overweight and intellectual disability at early ages of offspring conceived through IVF/ICSI.Overall,we suggest that women should have weight management before entering IVF/ICSI cycle for long-term children health. |
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