Study On Related Factors Of Cognitive Impairment In Patients With Parkinson’s Disease

Objectlive:To study the influence factors of mental retardation in patients with Parkinson’s disease,and its relationship with activities,daily life and serological indexes.Methods:Between January 2018 and January 2019,A total of 72 hospitalized patients with Parkinson’s disease in No.2 people’s hospital of Changshu were collected.According to the diagnostic criteria for mild cognitive impairment in Parkinson’s disease established by the movement disorders association of Chinese medical association in 2012,it can be divided into two groups:PDMCI group(36 cases)and PD cognitive normal group(36 cases).the Montreal cognitive assessment scale(MOCA),hoehn-yahr staging scale,unified Parkinson’s disease rating scale III(UPDRS)III,activities of daily living(ADL)were used to compare and analyze the basic data and clinical symptoms of the two groups.At last,the hematological indexes that affect PD cognition are evaluated and analyzed.SPSS19.0 and Graphpad 5.0 software were used to analyze and process the experimental data.Measurement data between the two groups were compared by Ttest,which was expressed by mean± standard deviation(x±S).The counting data between the two groups were tested by chi-square test.P<0.05 was considered statistically significant.Results1.Comparison of general data:there was no significant difference between the two groups in age,gender and income(P>0.05),while there was a significant difference in the number of years of education(P<0.05).With the increase of years of education,the occurrence of PD cognitive impairment decreased significantly.2.Comparison of the MOCA score between PDMCI group and PD cognitive normal group:there was no significant difference between the two groups in abstract power,delayed recall,naming power and orientation power(P>0.05),and there was significant difference in visual space,executive power,language and attention(P<0.05).The results indicated that PDMCI had serious impairment in visual space,executive ability,language and attention.3.Comparison of the number of h-y stages in PDMCI group and PD cognitive normal group:there was no significant difference in the number of people before and after 2.5 stages between the two groups(P>0.05).It shows that cognitive impairment can occur in early stage and staging has no effect on cognition.4.Comparison of UPDRS Ⅲ and ADL scores between PDMCI group and PD cognitive normal group:there were significant differences in UPDRS Ⅲ and ADL scores(P<0.05),indicating that the cognitive function decline of PD patients affected their activities and daily life ability.5.Patients in PDMCI group and PD cognitive normal group were divided into tremor type,ankylosis and gait obstacle dominant type and mixed type,and the number of cognitive impairment patients in ankylosis and gait obstacle dominant type was significantly greater than the other two types(P<0.05).6.Comparison of hematological indexes between PDMCI group and PD cognitive normal group:it can be seen that PD cognitive function is positively correlated with folic acid,vitamin B12 and uric acid(P<0.05),and negatively correlated with homocysteine(P<0.05).Conclusion1.PD patients have obvious impairment in visual space,executive ability,language and attention,and no significant influence in abstract ability,delayed recall,naming ability and orientation.2.The cognition of PD patients was positively correlated with years of education,UPDRS Ⅲ score,ADL score,folic acid,vitamin B12 and uric acid,and negatively correlated with homocysteine,but not correlated with age,gender,income and h-y stage.3.The cognition of PD patients was positively correlated with years of education,UPDRS Ⅲ score,ADL score,folic acid,vitamin B12 and uric acid,and negatively correlated with homocysteine,but not correlated with age,gender,income and h-y stage.PD patients with tetanus and gait disorders have more severe cognitive impairment than PD patients with tremor.