The Application Value Of MRC Combined With DCE-MRI In The Staging And Grading Of Golon Cancer

Objective:The purpose of this study was to investigate the value of magnetic resonance colonography(MRC)combined with dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)in the staging and grading of colon cancer.The correlation between DCE-MRI and tumor markers in staging and grading of colon cancer was also studied.Methods:18 patients diagnosed by colonoscopy with colon cancer in Hebei General hospital were collected from April 2018 to January 2019.All the patients underwent MRC,DCE-MRI examination and serum biochemical examination within 2 days after colonoscopy,surgery in one week and pathological examination was carried out after the operation.Imaging and clinical data of the 18 patients with colon cancer were prospectively studied.Taking pathological grading and staging as the gold standard,the staging diagnostic efficacy of MRC combined with DCE-MRI was statistically analyzed,and the correlation between DCE-MRI,tumor markers and pathological grading was also be analyzed.Results:① The accuracy of MRC combined with DCE-MRI in staging of T1-T4 colon cancer was 0%,0%,66.67%,84.62%,and the total accuracy was about 72.22%.The accuracy of N0-N2 stage was 57.14%,100%,100%,and the total accuracy was about 66.67%.② There was no significant difference in Kttans and Ve between the low and middle-grade groups,and in Kep was statistically significant.While no significant difference in Kep and Ve between the middle and high-grade groups,the difference in Ktrans was statistically significant.There was no significant difference in Kep between the low-grade and high-grade group,and the differences in Ktrans and Ve were statistically significant.③ There was no significant difference in ADC values between low and middle-grade groups,and between low and high-grade groups.There were statistically significant differences in ADC values between the low and high-grade groups.④ There were no significant differences in AFP,CEA and FERR between all groups,while there were statistically significant differences between all CA199 groups.⑤The grading of pathology showed a strong positive correlation with Krans and Kep,with statistical significance While there was a moderate negative correlation with Ve,with statistical significance.⑥ There was a strong negative correlation between pathological grade and ADC value,and the correlation was statistically significant.⑦There was no significant correlation between the pathological grade and AFP,CEA and FERR,and no statistical significance.It has a strong positive correlation with CA199 and has statistical significance.⑧ Ktrans and Kep were not significantly correlated with AFP,CEA and FERR,and neither had statistical significance.They have a strong positive correlation with CA199 and has statistical significance The Ve had a weak negative correlation with AFP,CA199 and FERR,and no statistical significance was found.There was a moderate positive correlation with CEA and no statistical significance.⑨ADC value had a weak negative correlation with AFP,and had no statistical significance.It has a strong negative correlation with CA199 and has statistical significance,and no significant correlation with CEA and no statistical significance.It has a weak positive correlation with FERR and is not statistically significant.⑩ADC value had a strong negative correlation with Ktrans and Kep,with statistical significance.And it has a moderate positive correlation with Ve value and no statistical significance.Conclusion:①MRC combined with DCE-MRI has higher diagnostic value in colon cancer staging.② The Kep between the low-grade and medium-grade,Ktrans between medium-grade and high-grade groups,Ktrans,Ve and ADC value between low-grade and high-grade groups were statistically significant,which can be used for the preliminary estimation of the grade of colon cancer.③The difference of CA199 between each group was statistically significant,and it can be used as one of the indicators to estimate the grading of colon cancer.④Ktrans and Kep were positively correlated with CA199 and pathological grading.ADC value was strongly negatively correlated with CA199,Ktrans,Kep and pathological grading,and the above indexes could be used to jointly predict the grade of colon cancer.