Studies Of Tumor Markers And ¹⁸F-FDG PET/CT Staging In Non Small Cell Lung Cancer

Objective:To analysis the correlation between tumor markers and PET/CT staging about non-small cell lung cancer(NSCLC).Methods:A retrospective analysis about of 254 NSCLC cases who both had the results of PET/CT examination and the tumor marker test(one week before or after PET/CT scan).There were 192 males(age 67±13) and 62 females(age55±14). These patients was detected and confirmed by pathology including 142 cases of adenocarcinoma, 92 cases of squamous cell carcinoma, 16 cases of glandular squamous cell carcinoma, and 4 cases of large cell carcinoma.Results:1. In NSCLC, the levels of CEA(p=0.038), CA125(p=0.026), CA242(p=0.046) are higher in adenocarcinoma, and the differences are statistically significant. The levels of SCC(p=0.007), CYF21-1(p<0.01) are higher in squamous cell carcinoma, and the differences are statistically significant. 2. In the adenocarcinoma group, the level of CEA and PET/CT staging has a positive correlation, rs=0.607(p<0.01); the levels of CA125,CA242 and PET/CT staging has no correlation(p>0.05). In squamous cell carcinoma group,the level of SCC and PET/CT staging has a positive correlation, rs=0.485(p<0.01); the level of CYF21-1 and PET/CT staging has no correlation(p>0.05). 3. Between the(Ⅰ+Ⅱ)group and(Ⅲ+Ⅳ) group, the differences of CEA(p=0.003), CA125(p=0.012), SCC(p=0.027), CYF21-1(p=0.034) were statistically significant.Conclusions:1. The tests of CEA, CA125, CA242 are more useful in the diagnosis aboutadenocarcinoma and the tests of SCC, CYF21-1 are more useful in the diagnosis about squamous cell carcinoma. 2. When predicting NSCLC PET/CT staging CEA and SCC have important reference values. 3. The levels of CEA, CA125, SCC, CYF21-1 maybe can guide the treatment options and prognosis in NSCLC patients.