| ObjectiveWith the development and progress of surgical techniques and instruments,laparoscopic surgery for colorectal cancer has been carried out and popularized.Laparoscopic surgery for colorectal cancer has the characteristics of less trauma,less blood loss,fewer days in hospital,low incidence of adverse reactions such as anastomotic leakage and incision infection.However,it still faces the problem of gastrointestinal dysfunction in different degrees after operation.Guided by the basic theory of traditional Chinese medicinethis subject aims to observe the effect of Champagne Prescription on the recovery of gastrointestinal function after laparoscopic colorectal cancer patients with Qi deficiency and qi stagnation by scientific research methods,and clarify the effect of Champagne Prescription gastrointestinal function recovery after laparoscopic surgery for colorectal malignant tumors so as to provide a safe and effective treatment of traditional Chinese medicine for the recovery of this disease after operation.MethodsThis study included 40 patients who underwent laparoscopic colorectal cancer surgery in the Anorectal Department of Guangdong Hospital of Traditional Chinese Medicine from January 2018 to December 2018.According to the principles and methods of clinical randomized controlled trials,the patients were randomly divided into experimental group(champagne formula+basic treatment group)and control group(placebo+basic treatment group),20 cases in each group.At 9:00 AM on the first day after operation,the experimental group was treated with champagne granules(areca nut 10g,ginseng 9g,black medicine 10g,Amomum seed 6g,peach seed 10g);the control group was treated with placebo,one dose a day,two warm doses,until the seventh day after operation(or the day of discharge).Record the general data of sex,age,weight,basic medical history and abdominal operation history.The operation methods,operation time and anesthesia time were counted.Record the time of first anal exhaust and defecation,recovery of total flow and half-flow diet after operation.Recovery indicators were recorded and adverse reactions such as nausea and vomiting,abdominal pain,abdominal distension and fever were recorded.Gastrointestinal function of dl,d2,D3 and D4 subjects was evaluated quantitatively,and D1-4 pain scores before and after operation were analyzed statistically.Mathematical statistical analysis model of preoperative and postoperative data of two groups of subjects was established by SPSS22.0 software.Independent sample t test was used for the measurement data,and Fisher' s exact probability method was used for the counting data.Non-normal distribution data were compared with two independent samples by nonparametric rank sum test.Results1.There was no significant difference in sex,age,weight,basic medical history and abdominal operation history between the two groups(P>0.05).2.There was no significant difference in WBC,Hb,PLT,ALB,transferrin and prealbumin between the two groups before operation(P>0.05).3.Statistical analysis was made on the intraoperative data such as operation mode,operation time,anesthesia time and intraoperative bleeding volume between the two groups.There was no significant difference between the two groups(P>0.05).There was no significant difference in the factors influencing the recovery of gastrointestinal function after operation,such as the time of indwelling urinary catheter,the time of indwelling gastric catheter,the time of indwelling abdominal drainage catheter,the days of rehydration and the days of antibiotic use(P>0.05).It shows that the baseline level of the two groups before treatment is uniform and comparable.4.The recovery time of gastrointestinal function after operation in two groups of subjects included in the experiment was analyzed statistically.The first defecation time(h)of champagne group was less than that of control group(P=0.00<0.05),and the first defecation time(h)of two groups of subjects included in the experiment was less than that of control group(P=0.00<0.05).Statistical analysis was made on the time needed for the two groups to resume full-flow diet and half-flow diet after operation.The Champagne prescription group was significantly better than the control group in shortening the time needed for resuming full-flow diet and half-flow diet after operation,with statistical significance.5.The adverse reactions of gastrointestinal tract such as nausea,vomiting and abdominal distension after operation in the two groups were analyzed.The difference between the two groups was statistically significant(P=0.03<0.05).Champagne prescription group can significantly improve the symptoms of gastrointestinal adverse reactions after operation.6.Quantitative score of gastrointestinal function recovery was made between the first day and the fourth day after operation.The gastrointest inal function score of the two groups increased day by day from the first day to the fourth day after operation,with a time effect.The difference has statistical significance,Along with the time effect(P=0.00<0.05).Th e difference has statistical significance,Along with the time effect(P=0.00<0.05).The differences between the champagne prescription group and the placebo group at the same time were further compared.The score of gastro intestinal function in the treatment group was significantly higher than that in the control group.The difference has statistical significance(P=0.00<0.05).There was interaction between D1,D2,D3 and D4 in treatment gro up and control group(F=30.388,P=0.000<0.05).7.The VAS pain scores of the two groups before and after operation from the first day to the fourth day were statistically analyzed.There were significant differences in VAS pain scores at each time point between the two groups(P=382.304,P=0.000<0.05).There were significant differences in VAS pain scores between the two groups(P=0.000<0.05).There was interaction between the two groups and time(P=0.003<0.05).The effect of time factors varied with the different groups.8.During the observation period,the drug compliance of the two groups included in the experiment was good(the number of times not taken was 0);no complications such as pulmonary infection,wound dehiscence occurred.ConclusionChampagne prescription has significant effect in promoting the recovery of gastrointestinal function in patients with colorectal cancer after laparoscopic surgery,which is embodied in shortening the time of automatic anal exhaust and defecation,shortening the time of full-flow diet and half-flow diet after operation.It is a safe and reliable Chinese medicine treatment for the recovery of gastrointestinal function after abdominal surgery. |
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