| Objective : To observe the contrast Chaiqin Sijin Decoction combined with ursodeoxycholic acid capsule and ursodeoxycholic acid capsule alone for the treatment of chronic calculous cholecystitis clinical curative effect of qi stagnancy and blood stasis,Gallbladder color Doppler ultrasound and gallbladder stone size improve performance,and security,explore the theoreticalbasis of ChaiqinSijin Decoction combined with ursodeoxycholic acid capsule in the treatment of this disease,and provide a new idea of the combination of Chinese and Western medicine for the treatment of this disease,in order to improve the cure rate in patients with qi stagnancy and blood stasis syndrome.Methods : From December 2017 to December 2018,66 patients with chronic calculous cholecystitis who met the inclusion and exclusion criteria in the Department of Gastroenterology and Inpatients of Shanxi Provincial Hospital of Integrated Traditional Chinese and Western Medicine were enrolled in the treatment group according to the principle of randomization and control.There were 33 cases in the treatment group and the control group.The control group was given oral ursodeoxycholic acid capsules,250 mg each time,once a day,4 weeks for a course of treatment,3 courses of continuous treatment;the treatment group was added with Chaiqi Sijin Decoction on the basis of the control group,daily 1 Agent,4 weeks for a course of treatment,continuous treatment for 3courses.Before and after treatment,the patients were scored with TCM syndrome score,gallbladder color Doppler score,stone size change,and the safety indexes and case shedding of the two groups were recorded.Statistical analysis was performed on the data collected by this experiment using SPSS 21.0 software.Results:1.General data comparison: There was no significant difference in gender,age and disease duration between the two groups(p>0.05),which was comparable.2.The degree of disease before treatment in the two groups: The two groups of patients had no statistical significance(P>0.05)in terms of TCM syndrome scores,gallbladder color Doppler,and stone size before treatment.3.Comparison of TCM syndrome scores: The clinical symptoms and signs of the control group were significantly improved compared with before treatment(p<0.01).After treatment,the TCM syndrome(pulse)improved after treatment(p<0.05),Chinesemedicine The main symptoms and other symptoms of TCM and signs improved significantly better than before treatment(p<0.01).After treatment,the improvement of TCM symptoms in the treatment group was significantly better than that in the control group(p<0.01).The goodness of the right,the right flank pain increased at night,the stool was unsatisfactory or the secret and the signs improved significantly better than the control group(p<0.01),but there was no significant difference in the improvement of TCM(linguistic,pulse)compared with the control group(p>0.05).4.Comparison of gallbladder color Doppler ultrasound: The control group and the treatment group had significant improvement in gallbladder color Doppler after treatment(p<0.01),but there was no significant difference in the improvement of gallbladder color ultrasonography between the two groups(p>0.05).5.Comparison of stone size: The size of stones in the control group and the treatment group was significantly improved compared with that before treatment(p<0.01),and the improvement of the treatment group was better than that of the control group(p<0.05).6.The total efficacy was compared: the total effective rate of the control group was59.38%,and the total effective rate of the treatment group was 87.50%.According to the rank sum test,the total curative effect of the treatment group was significantly better than that of the control group(z=-6.588,p<0.01).7.Comparison of safety: no adverse reactions occurred in the two groups of patients.Conclusion: Chaiqin Sijin Decoction combined with ursodeoxycholic acid capsule is effective in treating qi stagnation and blood stasis type chronic calculous cholecystitis,which can effectively improve the clinical symptoms,gallbladder color ultrasonography and stone size.The total effective rate is obviously better than that of single use.The treatment of ursodeoxycholic acid capsules is safe,but whether the improvement of gallbladder color Doppler ultrasound is better than the single drug is not clear,and further research is needed. |
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