| 1 Objective To observe the clinical efficacy of yangxue jiedu decoction in the treatment of Xuezao syndrome psoriasis vulgaris;to observe the changes of peripheral blood ILl-22 levelbefore and after treatment,in order to explore the partial mechanism of treatment of Yangxue Jiedu Decoction for Xuezao syndrome psoriasis vulgaris.2 Methods Will eventually be included in the study of Xuezao syndrome 60 patients with psoriasis vulgaris according to random number table method to the treatment group 30 cases and control group 30 cases,the physical examination center of 10 cases of normal person as treatment group 30 cases of normal control group patients give yangxue jiedu decoction with disease and subtract treatment,control group patients give hospital preparations after treatment Fufang zeqi infusion,The total treatment period for both groups was 8weeks,PASI score and TCM syndrome score of the two groups were recorded before treatment,4 weeks after treatment and 8 weeks after treatment,PASI scores and TCM syndrome scores of the two groups before treatment,4 weeks after treatment and 8weeks after treatment were statistically analyzed,and compared two groups of clinical curative effect of differences in the before and after each extraction treatment in treatment group and control group 2 ml of blood of the patient's elbow another 10 cases of normal elbow venous blood 2 ml,take the ELISA method for determining the expression level of IL-22 in the peripheral blood and the measured data analysis by SPSS software.3 Results3.1 PASI score of treatment group and control group PASI scores recorded during treatment in the treatment group and the control group were statistically analyzed.Before treatment,15.56 ± 4.16 in the treatment group was compared with 16.60 ± 3.25 in the control group.P > 0.05,the difference was not statistically significant.The PASI score of the treatment group was7.46±4.34 compared with 8.86 ± 3.89 of the control group,P > 0.05,the difference was not statistically significant.Treatment 8 weekend treatment group2.73±2.69 compared with the control group5.50±3.71,P < 0.05,the difference was statistically significant.3.2 TCM syndrome score of treatment group and control group The scores of TCM syndromes recorded in the treatment group and the control group were statistically analyzed.Pretreatment treatment group 15.56 ± 2.63 compared with control group 16.33±2.72,P >0.05,the difference was not statistically significant;After4 weeks of treatment 9.93 2.37 in the treatment group compared with 10.23 2.83 in the control group,P > 0.05,The difference was not statistically significant.After 8 weeks of treatment 4.66 ± 2.85 in the treatment group compared with 6.90 ± 2.82 in control group,P < 0.05,the difference was statistically significant.3.3 Clinical efficacy evaluation After Four weeks of treatmentt,Treatment group of 30 patients with desiccant psoriasis vulgaris,The cases of Clinical recovery ? Has obvious curative effect ? Has certain curative effect?invalid were 3?8?13 and 6,with cured and markedly effective rate of36.66%.Among the 30 patients in the control group,The cases of Clinical recovery?Has obvious curative effect?Has certain curative effect?invalid were 2?8 ?12and 8,with cured and markedly effective rate of 33.33%.The clinical efficacy of the two groups was compared by statistical analysis P >0.05,the difference was not statistically significant.After eight weeks of treatment,Treatment group of 30 patients with desiccant psoriasis vulgaris,The cases of Clinical recovery ? Has obvious curative effect ? Has certain curative effect?invalid were 11?14?5 and 0,respectively,with cured and markedly effective rate 83.33%.Control group 30 patients,The cases of Clinical recovery?Has obvious curative effect?Has certain curative effect?invalid were6?12?11and1,the cured and markedly effective rate was60%.The clinical efficacy between the two groups was P<0.05,and the difference was statistically significant.3.4 The Level of IL-22 Before treatment,IL-22 levels in the treatment group and the control group were(113.95±14.58?115.18±15.16),Compared with the normal control group(33.86±2.41)P <0.05,the difference was statistically significant.After the treatment,Il-22(53.86± 13.00)in the treatment group was lower than that before treatment(P<0.05).However,both were higher than normal(P <0.05),The level of IL-22(56.94±12.88)in the control group was lower than that before treatment(P <0.05).However,both were higher than normal(P <0.05).There was no significant difference in IL-22 between the treatment group and the control group(P >0.05).3.5 Safety comparison during treatment In the treatment group,2 patients showed epigastric discomfort,and 1 patient in the control group showed prolonged menstruation.The incidence of adverse reactions between the two groups(6.67% vs 3.33%)was compared.No statistically significant difference(P >0.05).4 Conclusion Yangxue jiedu decoction in the treatment of Xuezao syndrome psoriasis vulgaris clinical efficacy is positive,good safety.This study confirmed that the level of il-22 in peripheral blood of patients with psoriasis was higher than that of normal people.Yangxue jiedu decoction can significantly reduce the level of il-22 in peripheral blood of Xuezao syndrome psoriasis vulgaris... |
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