| Objective:The purpose of this study was to observe the effect and safety of stored autologous blood transfusion in Rh(D)-negative blood group transfusion,and to analyze the problems in the post-natal application of stored autologous blood transfusion,in order to improve the autologous blood transfusion and clinical promotion.Provide a practical basis.Methods:A retrospective study was conducted on 162 pregnant women with advanced Rh(D)-negative pregnancy who were scheduled for routine check-up and hospitalization in the Jiangxi Provincial Maternal and Child Health Hospital from July 2015 to December 2018.162 pregnant women(all met the criteria for autologous blood transfusion and have Blood collection)As the research object,48 women who had completed the return of autologous blood during the delivery process were used as the experimental group;35 women who underwent allogeneic blood transfusion were selected as the control group.Pregnant women in the experimental group were collected blood for 7-10 days before delivery at 38 weeks after gestation.Each time blood was collected 200 ml,the blood was stored for use;the control group was given allogeneic blood transfusion according to the amount of bleeding.The changes of hemoglobin(Hb),hematocrit(Hct)and platelet(PLT)levels in 162 pregnant women before blood collection and 3 days after blood collection were observed.The experimental group returned blood routine and level changes 3 days after transfusion.The maternal delivery and neonatal Apgar scores in the experimental group and the control group were compared.The postpartum hemorrhage,blood transfusion and hospitalization days of the two groups were compared.The incidence of adverse reactions after transfusion was recorded.Results:1.There was no significant difference in the general data,pregnancy comorbidity and prenatal blood routine indexes of Rh(D)negative pregnant women in experimental group and control group(P>0.05).2.The levels of RBC,Hb,Hct and PLT in 162 Rh(D)-negative pregnant women before pre-existing blood collection were not significantly different from those before blood collection(P>0.05).3,162 cases of Rh(D)negative pregnant women in the blood collection process,blood oxygen saturation was stable,fetal heart rate baseline and short-range variation was stable,there was no significant change in the indicators at each time(P> 0.05).4.There were no significant differences in the levels of RBC,Hb,Hct and PLT between the 48 pregnant women with Rh(D)negative blood type and the pre-transfusion(P>0.05).5.The cesarean section rate of the experimental group was 35.42%,the vaginal delivery rate was 64.58%;the cesarean section rate of the control group was 34.29%,and the vaginal delivery rate was 65.71%.There was no significant difference in the delivery mode between the two groups(P>0.05)..The neonatal delivery was good.There was no significant difference between the Apgar score of the newborn group and the Apgar score of the control group(P>0.05).6.There was no significant difference in postpartum hemorrhage volume and blood transfusion between the experimental group and the control group(P>0.05).However,the transfusion cost of the control group was significantly higher than that of the experimental group(P<0.05).The average length of hospital stay in the experimental group was(6.50±1.20)days,and the average length of hospital stay in the control group was(7.70±0.90)days.There was no significant difference in the number of hospital stays between the two groups(P>0.05).7.Observe and record the occurrence of adverse reactions after maternal blood transfusion.The experimental group had adverse reactions such as fever and infection,and no allergic and hemolysis occurred.The incidence rate was 6.25%.The incidence of adverse reactions such as fever,allergies,hemolysis and infection in the control group was about 34.28%.The incidence of adverse reactions in the control group was significantly higher than that in the experimental group,and the difference was statistically significant(P<0.05).Conclusions:1.Storage-type autologous blood transfusion has no significant effect on pregnant women and blood routine and childbirth,and does not affect the neonatal Apgar score,and the safety is good.2.storage-type autologous blood transfusion can reduce the cost of blood transfusion,and there are fewer adverse reactions than allogeneic blood transfusion.3.storage-type autologous blood transfusion can alleviate the blood supply and demand difficulties of pregnant Rh(D)negative bleeding in pregnant women,it is worth promoting in the clinic... |
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