Clinical Study Of The Relationship Between Metabolic Syndrome(MS) And Nephrolithiasis In Xinxiang City

ObjectiveMetabolic Syndrome(MS)is a series of physiological and metabolic disorder caused by co-occurring of central obesity,hypertension,raised triglycerides,elevated fasting glucose,lowered high-density lipoprotein cholesterol(HDL-C),with a year by year increasing prevalence.Urolithiasis is one of the common diseases in urology.The prevalence and incidence of urolithiasis are on the rise worldwide,and there are certain differences in gender,race and environment.Recent studies have shown that the prevalence of urolithiasis is closely related to components of metabolic syndrome related to lifestyle diseases such as obesity,hypertension,dyslipidemia and hyperglycemia.This study aims to understand the characteristics of urolithiasis in normal population and metabolic syndrome population in Xinxiang city through relevant data analysis.To uncover the association between metabolic syndrome and its components and the risk factors of urolithiasisin third-tier and fourth-tier inland cities in China at present through multivariable logistic regression analysis,and to provide scientific theoretical basis for the prevention and treatment of urolithiasis.MethodsWe obtained relevant datas from the population in Henan Xinxiang area between October 2016-October 2018 and 150 cases of urolithiasis patients and 635 cases of non-urolithiasispeople datain our hospital were included for statistical analysis.Then,we used case-control study to explorethe association of urolithiasis and metabolic syndrome and its components,using the single factor and the Logistic multi-factor regression analysis method to analyze and research the related influence factors of urolithiasis and to reveal the features of urolithiasis and related influence factorsin Xinxiang area.Results(1)There were significant differences in gender,age,BMI,systolic blood pressure,diastolic blood pressure,triglyceride,fasting glucose,uric acid and metabolic syndrome between the urolithiasis patients and non-urolithiasis groups(P<0.05).Total cholesterol,low-density lipoproteincholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-c),and urinary pH showed no significant difference(P>0.05).1.Femals had a significantly lower prevalence rate of urolithiasis than males(P<0.001).Femals were associated with a 0.269-fold increased risk of urolithiasis compared with males in our study(OR 0.269;95%CI 0.164–0.443;P<0.001)?.2.With the growth of age,the prevalence rate of urolithiasis in patients gradually increased,especially over 66 years old(P<0.05).The risk of urolithiasis was 3.657-fold increased in the elderly(?66 years old)compared with the young(18-40 years old)(OR3.657;95%CI 1.752–7.632;P<0.05);3.As the patient's blood pressure went up,the prevalence rate of urolithiasis increased significantly(P<0.01).People with higher blood pressure(systolic blood pressure ?130and/or diastolic blood pressure ?85)were associated with a 2.161-fold increased risk of urolithiasis compared with people with normal blood pressure(systolic blood pressure <130 and/or diastolic blood pressure < 85).(OR 2.161;95%CI 1.465–3.190;P<0.01)4.The prevalence rate of urolithiasis in the normal weight group(BMI < 25)was significantly lower than that in the overweight group(BMI ? 25),and P<0.01.The risk of urolithiasis was 1.833-fold increased in the overweight group(BMI ? 25)compared with the normal weight group(BMI < 25)(OR 1.833;95%CI 1.280–2.623;P<0.01);5.With the increased of fasting glucose and triglycerides,the prevalence rate of urolithiasis increased significantly(P<0.05).People with fasting glucose(?5.56 mmol/L)were associated with a 1.544-fold increased risk of urolithiasis compared with people with fasting glucose(<5.56 mmol/L).(OR 1.544;95%CI 1.080–2.206;P<0.01).People with triglycerides(?1.7 mmol/L)were associated with a 1.726-fold increased risk of urolithiasis compared with people with triglycerides(<1.7 mmol/L).(OR1.726;95%CI 1.206–2.468;P<0.01)6.The metabolic syndrome groups had a significantly higher prevalence rate of urolithiasis than the non-metabolic syndrome groups(P<0.001).The risk of urolithiasis was 1.722-fold increased in the metabolic syndrome groups compared with the non-metabolic syndrome groups(OR1.772;95%CI 1.239–2.536;P<0.01).As the number of metabolic syndrome components was 5,the incidence of urolithiasis was up to33.3%,reaching about 4.5-fold higher than that of 7.4% when the number of metabolic syndrome components was 0,and the difference was statistically significant.As the number of metabolic syndrome components increased from 2 to 5,the prevalence rate of urolithiasis increased significantly,with the OR ranging from 2.766 to 6.300,P<0.05.(2)Multivariable logistic regression analysis results showed that gender,age,blood pressure and uric acid have obvious correlation with the incidence of urolithiasis(P< 0.05).Successively,gender(OR:0.423;95%CI: 0.245-0.733;P=0.02);age(OR:3.126;95%CI:1.451-6.735;P=0.04);blood pressure(OR:1.638;95%CI:1.042-2.574;P=0.32);uric acid(OR: 1.003;95%CI:1.000-1.005;P=0.021)?Conclusions1.The prevalence rate of urolithiasis in female patients is significantly lower than male patients;With the growth of age,the prevalence rate of urolithiasis is higher in the elderly patients2.The components of metabolic syndrome: hypertension,high fasting glucose,high triglyceride,and overweight can reflect the severity of metabolic syndrome,and the prevalence rate of urolithiasis gradually increases with the increase of these indicators and the number of components.3.After univariate and multivariate regression analysis and adjusting for gender,age,we revealed that female was the protective factor of urolithiasis,with age,hypertension and uric acid were risk factors associated with urolithiasis.