| ObjectivesBisphenol A(BPA)is a kind of environmental endocrine disruptors(EDCs),which is widely used to produce polycarbonate and epoxy resin plastics.It can mimic estrogen effect,interfere normal brain development and cause cognitive behavioral developmental disorders in offspring.At present,many studies at domestic and foreign have revealed the neurobehavioral developmental toxicity of BPA,but the results are different.Therefore,this study aims to investigate the association between maternal BPA exposure and preschoolers’dietary behavior problems based on the description of the distribution characteristics of prenatal BPA exposure levels and preschoolers’dietary behavior problems,so as to provide scientific evidence-based evidence for the health care of pregnant women.MethodThe target population of this study was Ma’anshan birth cohort from China Anhui birth cohort study(C-ABCS).The cohort was recruited from October 2008 to October 2010among pregnant women receiving pregnancy care at four municipal health institutions in Ma’anshan City.For pregnant women who meet the inclusion criteria,use the“Maternal and Child Health record form during pregnancy and delivery period”to collect the general demographic information of pregnant women in the early,middle and late pregnancy,and the living and working environment exposure(noise,tobacco,alcohol consumption,past medical history,etc).The venous blood was collected from pregnant women during their first prenatal examination,the serum was separated and stored in the refrigerator of-80℃in Anhui Medical University.The concentrations of serum free BPA was determined by isotope dilution-solid extraction(SPE)coupled to high-performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS).A total of 5 084 pregnant women were enrolled in the cohort,pregnant women with spontaneous abortion(n=92),twins(n=66),and induced labor and stillbirth(n=55)and lost(n=202)were excluded during the follow-up.Finally,4 669 single live births were enrolled in the follow-up cohort of children.The seventh follow-up was conducted from April 2014 to June 2015,a total of 3 803 preschoolers were followed up.Collecting preschoolers’general demographic characteristics and information on dietary behaviors using the self-edited“Preschool Children’s Health Record Form”.From December 2012 to January 2014,a total of 2 452 pregnant women with serum free BPA concentrations were tested by follow-up time sequence.Among them,1 783 pregnant women in this study had serum BPA test data.Excluding 40 preschoolers with no dietary behaviors information,in the final,1 743 pairs of mothers and children were included in this analysis.The distribution characteristics of preschoolers,mothers’general demographic characteristics and BPA exposure level during pregnancy were statistically described.The BPA exposure level during pregnancy was divided into low(≤0.121 ng/mL),medium(0.121<BPA<0.393 ng/mL)and high exposure group(≥0.393 ng/mL).c~2was used to compare the distribution of serum free BPA in pregnant women with different demographic characteristics and the distribution characteristics of preschoolers’dietary behavior problems.The multivariate polynomial logistic regression model was used to investigate the association between maternal BPA exposure and dietary behavior problems of preschoolers.ResultsIn this analysis,the serum free BPA concentrations during pregnancy was 0.001 to20.718 ng/mL,and the median concentration was 0.232(0.106,0.519)ng/mL.The age of preschoolers was range from 40 to 68 months,with an average age of(50.86±5.03)months.Dietary behavior survey results showed that about 11.7%(204/1 743)of preschoolers can not eating independently,4.8%(83/1 743)of preschoolers are always unable to eat happily,30.0%(523/1 743)of preschoolers have a problem of eating picky eaters,11.6%(202/1 743)of preschoolers have more than 30 minutes of eating time,10.1%(176/1 743)of preschoolers prefer to a salty taste,and 16.0%(279/1 743)of preschoolers prefer to a sweet taste.Multivariate polynomial logistic regression analysis showed that prenatal BPA exposure was a risk factor for dietary behavior problems among preschoolers.That is,comparing with the BPA low-exposure group,the risk of preschoolers can not eating independently in BPA medium and high-exposure groups were 1.752 and 1.633 times than the preschoolers in the BPA low-exposure group(OR=1.752,95%CI:1.135~2.705;OR=1.633,95%CI:1.044~2.556);Comparing with BPA low exposure group,the risk of preschoolers with preference for salty food in BPA medium and high-exposure groups were 1.637 and 1.771 times than the preschoolers in the BPA low exposure group(OR=1.637,95%CI:1.064~2.520;OR=1.771,95%CI:1.135~2.761).No statistical association was found between maternal prenatal BPA exposure and preschoolers’eating mood,picky eating behavior and eating time(P>0.05).ConclusionMaternal BPA exposure increases the risk that preschoolers can not eating independently and the preference for salty taste.Since the sensitivity of brain development to EDCs,it is suggested that the pregnant women should keep away from BPA products during pregnancy to reduce the damage of BPA exposure to maternal and child health. |
